갑상선기능항진증에 동반된 고칼슘혈증 1예 = A Case of Hyperthyroidism Associated with Symptomatic Hypercalcemia

다국어 초록 (Multilingual Abstract)

Two of the common causes of hypercalcemia are malignancy and primary hyperparathyroidism. These disorders are easily diagnosed by the clinical manifestations and measurement of the serum intact parathyroid hormone (PTH) level. On the other hand, hyperthyroidism is an uncommon cause of hypercalcemia. The diagnosis of hypercalcemia associated with hyperthyroidism can only be made by excluding the common causes of hypercalcemia and by observing the improvement of the hypercalcemia and its associated symptoms with normalizing the thyroid function. Herein we reported our experience with a 67 year-old woman who presented with nausea and vomiting. She showed elevated serum calcium and phosphorus levels. Serum intact PTH level was 1.1 pg/mL (normal range; 10~65). The results of the thyroid function test were compatible with hyperthyroidism. After resolution of the thyrotoxicosis with combination treatment of methimazol and Lugol's solution, the patient's serum calcium and phosphorus levels were normalized and the symptoms were improved. (J Kor Soc Endocrinol 21:251~256, 2006)

국문 초록 (Abstract)

갑상선기능항진증의 가장 흔한 원인으로는 악성종양과 일차성 부갑상선기능항진증을 들 수 있으며, 이들 질환은 임상양상과 혈중 intact PTH 측정을 통해 진단할 수 있다. 반면, 갑상선기능항진증은 고칼슘혈증의 드문 원인 중의 하나로, 갑상선기능항진증에 의한 고칼슘혈증은 대부분의 경우 임상양상이 경미하며 고칼슘혈증의 흔한 원인들을 배제한 후 갑상선 기능이 정상화되면서 고칼슘혈증이 호전되는 것으로 진단이 가능하다. 저자들은 오심과 구토 증상으로 내원한 67세 여자환자에서 갑상선기능항진증과 동반된 고칼슘혈증을 관찰하였고, 항갑상선제와 루골용액, propranolol을 병용하여 갑상선기능을 정상화 시킨 후 환자의 증상 및 칼슘 수치가 정상화된 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

참고문헌 (Reference)

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