인공수정체안에서 마이토마이신 섬유주절제술과 아메드 밸브삽입술의 임상 성적 = Trabeculectomy with Mitomycin C versus Ahmed Valve Implantation in Pseudophakic Glaucomatous Eyes

다국어 초록 (Multilingual Abstract)

`Purpose: To compare the safety and efficacy of trabeculectomy using mitomycin C (MMC) with Ahmed valve implantation in pseudophakic glaucomatous eyes. Methods: We retrospectively reviewed the medical records of 68 pseudophakic glaucoma patients (68 eyes) who had undergone trabeculectomy with MMC (group T, 41 eyes) or Ahmed valve implantation (group A, 27 eyes). Intraocular pressure reduction rates, cumulative probabilities of surgical success, and postoperative complications were compared between two groups. Also, risk factors for surgical failures were analyzed. Results: Intraocular pressure levels at postoperative 12 months were significantly lower in group T (13.8±5.1 mmHg) than in group A (19.6±6.4 mmHg, p=0.001). Cumulative probabilities of surgical success at postoperative 12 months were significantly higher in group T (95.0%) than in group A (66.2%, p=0.000). No significant differences were noted in the occurrences of complications except hyphema in two groups. We found that a younger age (≤50 years) and Ahmed valve implantation were significant risk factors for surgical failures. Conclusions: Trabeculectomy with MMC can be more effective and preferable as a primary surgical option over Ahmed valve implantation for pseudophakic glaucomatous eyes.`

참고문헌 (Reference)

1 김도현, "합병증을 중심으로 본 아메드 밸브 삽입의 임상성적" 대한안과학회 44 (44): 888-895, 2003

2 이양원, "아메드 방수유출장치 삽입수술의 성공과 관련된 요인" 대한안과학회 46 (46): 1509-1517, 2005

3 이상협, "난치성 녹내장에서 아메드 방수유출장치 삽입술의 효과" 대한안과학회 48 (48): 83-90, 2007

4 이현주, "난치성 녹내장에서 아메드 녹내장밸브 삽입술의 임상적 고찰" 대한안과학회 47 (47): 933-940, 2006

5 Skuta GL, "Wound healing in glaucoma filtering surgery" 32 : 149-170, 1987

6 Krupin T, "Valve implants in filtering surgery" 81 : 232-235, 1976

7 Gedde SJ, "Treatment outcomes in the tube versus trabeculectomy study after one year of follow-up" 143 : 9-22, 2007

8 Broadway DC, "Trabeculectomy, risk factors for failure and the preoperative state of the conjunctiva" 10 : 237-249, 2001

9 Kitazawa Y, "Trabeculectomy with mitomycin. A comparative study with fluorouracil" 109 : 1693-1698, 1991

10 Fontana H, "Trabeculectomy with mitomycin C in pseudophakic patients with open-angle glaucoma: outcomes and risk factors for failure" 141 : 652-659, 2006

11 Prata JA Jr, "Trabeculectomy in pseudophakic patients: postoperative 5-fluorouracil versus intraoperative mitomycin C antiproliferative therapy" 26 : 73-77, 1995

12 Heuer DK, "Trabeculectomy in aphakic eyes" 1045-1051, 1984

13 Gedde SJ, "The tube versus trabeculectomy study: Design and baseline characteristics of study patients" 140 : 275-287, 2005

14 Herschler J, "The effect of total vitrectomy on filtration surgery in the aphakic eye" 88 : 229-232, 1981

15 Kim DH, "The effect of mitomycin C on primary trabeculectomy: comparative study in the same person" 39 : 2129-2135, 1998

16 "The Fluorouracil Filtering Surgery Study Group. Five-year follow-up of the Fluorouracil Filtering Surgery Study" 121 : 349-366, 1996

17 Gross RL, "Surgical therapy of chronic glaucoma in aphakia and pseudophakia" 95 : 1195-1201, 1988

18 Bellow AR, "Surgical management of chronic glaucoma in aphakia" 90 : 807-813, 1983

19 Gedde SJ, "Surgical complications in the tube versus trabeculectomy study during the first year of follow-up" 143 : 23-31, 2007

20 Molteno AC, "Otago glaucoma surgery outcome study, Long-term results of trabeculectomy- 1976 to 1995" 106 : 1742-1750, 1999

21 Molteno AC, "New implant for drainage in glaucoma: Clinical Trial" 53 : 606-615, 1969

22 Palmer SS, "Mitomycin as adjunct chemotherapy with trabeculectomy" 98 : 317-321, 1991

23 Lee SM, "Mitomycin C trabeculectomy for uncomplicated glaucoma: a comparison between 0.25 and 0.5mg/ml of mitomycin C" 37 : 119-128, 1996

24 Wilson MR, "Long-term follow-up of primary glaucoma surgery with Ahmed glaucoma valve implant versus trabeculectomy" 136 : 464-470, 2003

25 Greenfiled DS, "Late-onset bleb leaks after glaucoma filtering surgery" 116 : 443-447, 1998

26 Skuta GL, "Intraoperative mitomycin versus postoperative 5-fluorouracil in high-risk glaucoma filtering surgery" 99 : 438-444, 1992

27 Hansen MH, "Intraocular pressure seven years after extracapsular cataract extraction and sulcus implantation of posterior chamber intraocular lens" 21 : 676-678, 1995

28 Hansen TE, "Intraocular pressure 2 1/2 years after extracapsular cataract extraction and sulcus implantation of posterior chamber intraocular lens" 69 : 225-228, 1991

29 Huang MC, "Intermediate-term clinical experience with the Ahmed glaucoma valve implant" 127 : 27-33, 1999

30 Lloyd MA, "Initial clinical experience with the Baerveldt implant in complicated glaucomas" 101 : 640-650, 1994

31 Coleman AL, "Initial clinical experience with Ahmed glaucoma valve implant" 120 : 23-31, 1995

32 Jamil AL, "Glaucoma tube or trabeculectomy? That is the question" 143 : 141-142, 2007

33 Levene RZ, "Glaucoma filtering surgery. factors that determine pressure control" 15 : 475-483, 1984

34 Schwartz KS, "Glaucoma drainage implants: a critical comparison of types" 17 : 181-189, 2006

35 Lee VW, "Glaucoma "valves"-truth versus myth" 105 : 567-568, 1998

36 Beckers HJ, "Five-year results of trabeculectomy with mitomycin C" 241 : 106-110, 2003

37 Cho YS, "Filtering surgery in aphakia and pseudophakia" 34 : 135-140, 1993

38 Blindlish R, "Efficacy and safety of mitomycin-C in primary trabeculectomy: five-year follow-up" 109 : 1336-1341, 2002

39 Hong C, "Effects of topical mitomycin C on glaucoma filtration surgery" 34 : 865-874, 1993

40 Im Y, "Comparison of mitomycin C trabeculectomy and Ahmed valve implant surgery for neovascular glaucoma" 45 : 1515-1521, 2004

41 Lee DS, "Comparison of long-term results of primary trabeculectomy with mitomycin C in juvenile-onset and adult-onset primary open angle glaucoma" 43 : 2466-2474, 2002

42 Shileds MB, "Clinical and histopathologic observations concerning hypotony after trabeculectomy with adjunctive mitomycin C" 116 : 673-683, 1993

43 Francis BA, "Characteristics of glaucoma drainage implants during dynamic and steadystate flow conditions" 105 : 1708-1714, 1998

44 Wilson MR, "Ahmed glaucoma valve implant vs trabeculectomy in the surgical treatment of glaucoma: a randomized clinical trial" 130 : 267-273, 2000

45 Lamping KA, "5-fluorouracil and mitomycin C in pseudophakic patients" 102 : 70-75, 1995