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      식물추출복합물(CME)의 퇴행성관절염 개선효과 = Beneficial Effects of Phyto-Extract Complex (CME) on Degenerative Arthritis

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      https://www.riss.kr/link?id=A99850609

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      Objectives: Degenerative arthritis arises from several physiological factors. The purpose of this study is to investigate the beneficial effects of Phyto-extract Complex (CME) on degenerative arthritis. Methods : CME is composed of extracts of mulberry (Morus alba L.) fruit, mulberry leaves and black beans (Glycine max (L.) Merr.). To measure the toxicity of CME, we performed the single-dose toxicity study. For the evaluation of its effects on degenerative arthritis, we examined the inhibition of cyclooxygenase-2 (COX-2) activity, using in vitro enzyme activity assay, the reduction of protein expression of COX-2, 5-lipoxygenase (5-LO), and inducible nitric oxide synthase (iNOS) in RAW264.7 cells which were stimulated by lipopolysaccharide (LPS). We also examined the serum level of prostaglandins (PGs) and injury of the knee joint cartilage, using animal model of degenerative arthritis induced by mono-sodium iodoacetate (MIA). Results : CME did not have any toxicity in single-dose toxicity study. The CME inhibited the activity of COX-2 and could reduce the protein expression of COX-2, 5-LO and iNOS in RAW264.7 cells. The CME also reduced the serum level of PGs and prevented from the cartilage injury of knee joint in animal model of degenerative arthritis induced by MIA. Conclusions : Taken altogether, the CME could be useful for the improvement of degenerative arthritis through its various anti-inflammatory activities and prevention from the cartilage injury of knee joint.
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      Objectives: Degenerative arthritis arises from several physiological factors. The purpose of this study is to investigate the beneficial effects of Phyto-extract Complex (CME) on degenerative arthritis. Methods : CME is composed of extracts of mulberr...

      Objectives: Degenerative arthritis arises from several physiological factors. The purpose of this study is to investigate the beneficial effects of Phyto-extract Complex (CME) on degenerative arthritis. Methods : CME is composed of extracts of mulberry (Morus alba L.) fruit, mulberry leaves and black beans (Glycine max (L.) Merr.). To measure the toxicity of CME, we performed the single-dose toxicity study. For the evaluation of its effects on degenerative arthritis, we examined the inhibition of cyclooxygenase-2 (COX-2) activity, using in vitro enzyme activity assay, the reduction of protein expression of COX-2, 5-lipoxygenase (5-LO), and inducible nitric oxide synthase (iNOS) in RAW264.7 cells which were stimulated by lipopolysaccharide (LPS). We also examined the serum level of prostaglandins (PGs) and injury of the knee joint cartilage, using animal model of degenerative arthritis induced by mono-sodium iodoacetate (MIA). Results : CME did not have any toxicity in single-dose toxicity study. The CME inhibited the activity of COX-2 and could reduce the protein expression of COX-2, 5-LO and iNOS in RAW264.7 cells. The CME also reduced the serum level of PGs and prevented from the cartilage injury of knee joint in animal model of degenerative arthritis induced by MIA. Conclusions : Taken altogether, the CME could be useful for the improvement of degenerative arthritis through its various anti-inflammatory activities and prevention from the cartilage injury of knee joint.

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      참고문헌 (Reference)

      1 이숙희, "오디 추출물의 혈관신생 억제 효과" 한국생명과학회 18 (18): 653-659, 2008

      2 오숙, "시판되는 밥밀콩류의 이소플라본 함량, 항산화활성 및 혈전용해활성" 한국식품과학회 34 (34): 498-504, 2002

      3 전연희, "서리태 에탄올 추출물의 항산화 활성 및 암세포 증식 억제 효과" 한국식품조리과학회 27 (27): 1-10, 2011

      4 배만종, "뽕잎발효차 제조에 따른 항산화 및 in vitro 항암활성" 한국식품영양과학회 39 (39): 796-804, 2010

      5 김은옥, "뽕나무(Morus alba L.) 품종별 오디의 영양 및 기능성 성분과 이화학적 품질 특성 비교" 한국식품영양과학회 39 (39): 1467-1475, 2010

      6 김오곤, "고혈당 흰쥐에서 桑葉의 혈당 조절과 항산화 작용에 관한 연구" 대한한방내과학회 27 (27): 811-821, 2006

      7 김용호, "검정콩 안토시아닌의 항산화 및 암세포독성" 한국작물학회 53 (53): 407-412, 2008

      8 de Boer TN, "The chondroprotective effect of selective COX-2 inhibition in osteoarthritis: ex vivo evaluation of human cartilage tissue after in vivo treatment" 17 (17): 482-488, 2009

      9 Kim HB, "The analysis of functional materials in mulberry fruit and food product development trends" 36 : 49-60, 2003

      10 Yeom HE, "Symptoms, aging-stereotyped beliefs, and health-promoting behaviors of older women with and without osteoarthritis" 34 (34): 307-313, 2013

      1 이숙희, "오디 추출물의 혈관신생 억제 효과" 한국생명과학회 18 (18): 653-659, 2008

      2 오숙, "시판되는 밥밀콩류의 이소플라본 함량, 항산화활성 및 혈전용해활성" 한국식품과학회 34 (34): 498-504, 2002

      3 전연희, "서리태 에탄올 추출물의 항산화 활성 및 암세포 증식 억제 효과" 한국식품조리과학회 27 (27): 1-10, 2011

      4 배만종, "뽕잎발효차 제조에 따른 항산화 및 in vitro 항암활성" 한국식품영양과학회 39 (39): 796-804, 2010

      5 김은옥, "뽕나무(Morus alba L.) 품종별 오디의 영양 및 기능성 성분과 이화학적 품질 특성 비교" 한국식품영양과학회 39 (39): 1467-1475, 2010

      6 김오곤, "고혈당 흰쥐에서 桑葉의 혈당 조절과 항산화 작용에 관한 연구" 대한한방내과학회 27 (27): 811-821, 2006

      7 김용호, "검정콩 안토시아닌의 항산화 및 암세포독성" 한국작물학회 53 (53): 407-412, 2008

      8 de Boer TN, "The chondroprotective effect of selective COX-2 inhibition in osteoarthritis: ex vivo evaluation of human cartilage tissue after in vivo treatment" 17 (17): 482-488, 2009

      9 Kim HB, "The analysis of functional materials in mulberry fruit and food product development trends" 36 : 49-60, 2003

      10 Yeom HE, "Symptoms, aging-stereotyped beliefs, and health-promoting behaviors of older women with and without osteoarthritis" 34 (34): 307-313, 2013

      11 Kim MH, "Study on the usability of mulberry fruit. Fruit characteristics of mulberry" 5 : 221-223, 1980

      12 박정섭, "Streptozotocin 유발 당뇨 백서에 桑葉 枳殼 혼합물의 항당뇨 및 혈관탄성개선 효과" 대한한방내과학회 28 (28): 544-559, 2007

      13 Park SW, "Quantitative analysis of anthocyanins among mulberry cultivars and their pharmacological screening" 38 : 722-724, 1997

      14 Kraan PM, "Osteoarthritis in the context of ageing and evolution Loss of chondrocyte differentiation block during ageing" 7 : 106-113, 2008

      15 Shin HC, "Nutritional adequacy and beneficial effects of soy formula" 18 : 10-25, 2001

      16 Niidome T, "Mulberry leaf extract prevents amyloid beta-peptide fibril formation and neurotoxicity" 18 (18): 813-816, 2007

      17 Wang S, "Inhibition of vascular smooth muscle cell proliferation by serum from rats treated orally with Gastrodia and Uncaria decoction, a traditional Chinese formulation" 114 (114): 458-462, 2007

      18 Bédouet L, "In vitro evaluation of (S)-ibuprofen toxicity on joint cells and explants of cartilage and synovial membrane" 25 (25): 1944-1952, 2011

      19 Kim HB, "Identification of C3G (cyanidin-3 glucoside) from mulberry fruits and quantification with different varieties" 45 : 1-5, 2003

      20 Kim HJ, "Effects of Mori folium and Crataegus pinnatifida leave extracts on CCl4-induced hepatotoxicity in rats" 47 (47): 2006-2011, 2003

      21 Katsube T, "Effect of air-drying temperature on antioxidant capacity and stability of polyphenolic compounds in mulberry(Morus alba L.) leaves" 113 : 964-969, 2009

      22 Pirvulescu MM, "Curcumin and a Morus alba extract reduce pro‐Inflammatory effects of resistin in human endothelial cells" 25 : 1737-1742, 2011

      23 Laine L, "COX-2 selective inhibitors in the treatment of osteoarthritis" 38 (38): 165-187, 2008

      24 Chang MC, "Accumulation of mitochondrial DNA with 4977-bp deletion in knee cartilage e an association with idiopathic osteoarthritis" 13 : 1004-1011, 2005

      25 Kim TW, "A study on the antidiabetic effect of mulberry fruits" 38 : 100-107, 1996

      26 Galliard-Grigioni KS, "A randomized, controlled study on the influence of acetaminophen, diclofenac, or naproxen on aspirin-induced inhibition of platelet aggregation" 609 (609): 96-99, 2009

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      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2026 평가예정 재인증평가 신청대상 (재인증)
      2020-01-01 평가 등재학술지 유지 (재인증) KCI등재
      2017-01-01 평가 등재학술지 유지 (계속평가) KCI등재
      2013-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2008-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2006-09-15 학술지등록 한글명 : 대한본초학회지
      외국어명 : The Korea Journal of Herbology
      KCI등재
      2005-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2004-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2002-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.57 0.57 0.54
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.55 0.54 0.912 0.11
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