Vapor-phase synthesis of a robust polysulfide film for transparent, biocompatible, and long-term stable anti-biofilm coating

다국어 초록 (Multilingual Abstract)

Biofilm formation caused by the fouling of microorganisms is one of the major problems in biomedicaldevices, food industry, and marine transportation. Since the removal of adherent biofilm is not a trivial task, it is ofparamount importance to contain the formation of the anti-biofilm film. Herein, a polysulfide-based anti-biofilm coating(PAC) equipped with full transparency, non-toxicity, and environmental stability was developed via a simple vaporphasesynthesis. The polymer coating consists of polysulfide chain grafted onto poly (1,3,5,7-tetramethyl-1,3,5,7-tetravinylcyclotetrasiloxane) (pV4D4) layer via thiol-ene click reaction, which was accomplished via a sequential depositionof each polymer followed by UV irradiation. The pV4D4 served as an adhesion promoter layer that substantiallyenhanced the interfacial adhesion between polysulfide layer and various substrate materials. The polysulfide layerexhibits a long-lasting anti-biofilm performance against pathogenic bacteria, such as Escherichia coli: O157 and Staphylococcusaureus. The excellent anti-biofilm property is attributed to slippery surface derived from the non-adherent,dynamic characteristics of the polysulfide (-S-S-) chain. The anti-biofilm coating indeed shows outstanding durabilityand robustness when exposed to extreme pH, organic solvents, and mechanical stresses. The fully transparent, robustcoating developed in this study is a promising candidate material for a broad range of anti-biofilm applications.

참고문헌 (Reference)

1 J. A. Shapiro, 52 : 81-, 1998

2 B. Y. Li, 36 : 22-, 2018

3 Y. Choi, 270 : 445-, 2019

4 J. W. Costerton, 285 : 74-, 2001

5 C. G. Kumar, 42 : 9-, 1998

6 K. K. Chung, 2 : 89-, 2007

7 B. Meyer, 51 : 249-, 2003

8 L. Zhang, 9 : 3027-, 2014

9 C. M. Grozea, 5 : 4088-, 2009

10 A. M. C. Maan, 30 : 2000936-, 2020

11 S. Gon, 27 : 15083-, 2011

12 C. Yang, 26 : 7346-, 2014

13 W. F. Yu, 4 : 2385-, 2021

14 D. Y. Dong, 7 : eabc5442-, 2021

15 C. Leng, 40 : 6-, 2016

16 K. Chae, 6 : eabb0025-, 2020

17 Z. G. Guo, 127 : 15670-, 2005

18 J. Genzer, 22 : 339-, 2006

19 R. Poetes, 105 : 166104-, 2010

20 H. F. Bohn, 101 : 14138-, 2004

21 A. K. Epstein, 109 : 13182-, 2012

22 T. -S. Wong, 477 : 443-, 2011

23 T. S. Kleine, 9 : 245-, 2020

24 R. Martin, 25 : 084017-, 2016

25 J. J. Griebel, 4 : 862-, 2015

26 R. Xu, 3 : 833-, 2013

27 J. J. Griebel, 58 : 90-, 2016

28 D. H. Kim, 6 : eabb5320-, 2020

29 W. Jang, 13 : 61629-, 2021

30 H. Kim, 32 : 2113253-, 2022

31 J. Liu, 33 : 2100237-, 2021

32 A. G. Gristina, 237 : 1588-, 1987