Daily intake of polyamine-rich Saccharomyces cerevisiae S631 prevents osteoclastic activation and bone loss in ovariectomized mice

다국어 초록 (Multilingual Abstract)

An imbalance in the sophisticated regulationbetween bone-resorbing osteoclasts and bone-formingosteoblasts leads to the pathogenesis and etiology of certainmetabolic bone diseases including osteoporosis. Certainpolyamines are related to the pathophysiology of some disorders,including Alzheimer’s disease, infectious disease,cancer, and aging. Recently, we demonstrated that oralintake of polyamines (spermidine and spermine) preventedbone loss through preferential disturbance of osteoclasticactivation in ovariectomy-induced mouse model of postmenopausalosteoporosis. Here, we showed that daily oralsupplementation of a diet containing polyamine-rich Saccharomycescerevisiae S631 significantly inhibited osteoclasticactivation as well as reduction of bone volume in thecancellous bone without affecting uterine weight inovariectomized mice. Our findings recommend that dailyoral supplementation with polyamine-rich yeast diet wouldbe beneficial for prophylaxis of metabolic bone diseasesassociated with abnormal osteoclast activation.

참고문헌 (Reference)

1 Iezaki T, "Transcriptional Modulator Ifrd1 Regulates Osteoclast Differentiation through Enhancing the NF-kappaB/NFATc1 Pathway" 36 : 2451-2463, 2016

2 Yamamoto T, "The natural polyamines spermidine and spermine prevent bone loss through preferential disruption of osteoclastic activation in ovariectomized mice" 166 : 1084-1096, 2012

3 Chen X, "Osteoblast-osteoclast interactions" 59 : 99-107, 2018

4 Hinoi E, "Glutamate suppresses osteoclastogenesis through the cystine/glutamate antiporter" 170 : 1277-1290, 2007

5 Wagner EF, "Genetic control of skeletal development" 11 : 527-532, 2001

6 Feng X, "Disorders of bone remodeling" 6 : 121-145, 2011

7 Igarashi K, "Characteristics of cellular polyamine transport in prokaryotes and eukaryotes" 48 : 506-512, 2010

8 Weiger TM, "Cell proliferation, potassium channels, polyamines and their interactions: a mini review" 46 : 681-688, 2014

9 Parfitt AM, "Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee" 2 : 595-610, 1987

10 Fukasawa K, "ATF3 controls proliferation of osteoclast precursor and bone remodeling" 6 : 30918-, 2016

11 Hunter KJ, "A dansyl chloride-HPLC method for the determination of polyamines" 79 : 119-123, 1998