Simulation of Oral Glucose Tolerance Tests and the Corresponding Isoglycemic Intravenous Glucose Infusion Studies for Calculation of the Incretin Effect

다국어 초록 (Multilingual Abstract)

The incretin effect, which is a unique stimulus of insulin secretion in response to oralingestion of nutrients, is calculated by the difference in insulin secretory responses from anoral glucose tolerance test (OGTT) and a corresponding isoglycemic intravenous glucoseinfusion (IIGI) study. The OGTT model of this study, which is individualized by fitting theglucose profiles during an OGTT, was developed to predict the glucose profile during an IIGIstudy in the same subject. Also, the model predicts the insulin and incretin profiles duringboth studies. The incretin effect, estimated by simulation, was compared with thatmeasured by physiologic studies from eight human subjects with normal glucose tolerance,and the result exhibited a good correlation (r > 0.8); the incretin effect from the simulationwas 56.5% ± 10.6% while the one from the measured data was 52.5% ± 19.6%. Inconclusion, the parameters of the OGTT model have been successfully estimated to predictthe profiles of both OGTTs and IIGI studies. Therefore, with glucose data from the OGTTalone, this model could control and predict the physiologic responses, including insulinsecretion during OGTTs and IIGI studies, which could eventually eliminate the need forcomplex and cumbersome IIGI studies in incretin research.

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