Methylmethacrylate Monomer의 가토 신장기능에 미치는 영향 : Effects of Methylmethacrylate Monomer on the Renal Function in Rabbits

다국어 초록 (Multilingual Abstract)

Relating to toxicity of methylmethacrylate monomer, there are many evidences of pathological changes, ie. parenchymal degeneration in pulmonary, hepatic, and renal tissue of animal with high dosage. But the reports about the effects of methylmethacrylate monomer on renal function are rare. Therefore the author intended to investigate the effects of methylmethacrylate monomer on parameters of renal function. Experimental dosages of methylmethacrylate monomer were 0.1㎕/min and 0.25㎕/min, of which didn't cause the arterial hypotension. The infusion was perfermed at a rate of 30 ml/hr for 1 hour.
During the one hour periods of administration of methylmethacrylate and recovery proces blood and urine samples were collected and analyzed. Plasma clearances of substances various were obtained by the measuring the plasma and urine concentrations of inulin, PAH, osmolarlty sodium and potassium.
The results were summarized as follows.
1. Glomerular filtration rate and renal plasma flow were not affected at a dose of
but tended to decrease at a dose of 0.25ul/min of methylmethacrylate monomer.
2. Urine flow was reduced significantly (p<0.05) by methylmethacrylate monomer.
3. Urine osmolarity was increased significantly (p<0.05) by methylmethacrylate monomer.
4. Negative free water clearance was increased significantly (p<0.05) by methylmethacrylate monomer.
5. Osrnolar clearance and sodium and potassium reabsorption rate were not affected significantly by methylmethacrylate monomer.
From the above results, it was suggests that methylmethacrylate monomer caused the reduction of urine flow through enhancement of tubular free water reabsorption and partially affecting the GFR and RPF.