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      신원방우황청심원의 심혈관계에 관한 약효 = Pharmacological Actions of New Wonbang Woohwangchungsimwon Pill on Cardiovascular System

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      https://www.riss.kr/link?id=A19598365

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      다국어 초록 (Multilingual Abstract)

      Abstract-In order to investigate the phamacological properties of New Wonbang Woohwangchungsimwon Pill (NSCH), effects of Wonbang Woohwangchungsimwon Pill (SCH) and NSCH were compared using various experimental models. In rat aorta, NSCH and SCH made the relaxation of blood vessels in maximum contractile response to phenylephrine (10^-6 M) regardless to endothelium containing or denuded rings of the rat aorta. Furthermore, the presence of the inhibitors of NO synthase and guanylate cyclase did not aftect significantly the relaxing effects of NSCH and SCH, NSCH and SCH inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs). NSCH and SCH decreased significantly heart rate. These, at high doses, had a negative inotropic effect that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In guinea-pig papillary muscle, these had no effects on parameters of action potential such as action potential amplitude (APA). V_max and resting membrane potential (RMP) at low doses, whereas inhibited the cardiac contractility at high doses. Furthermore, these had a significant inhibitory effects on palpitation of the heart in normotensive rats and SHRs. These results suggest that NSCH and SCH have weak cardiovascular effects, and that there is no significant differences between cardiovascular effects of two preparations.
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      Abstract-In order to investigate the phamacological properties of New Wonbang Woohwangchungsimwon Pill (NSCH), effects of Wonbang Woohwangchungsimwon Pill (SCH) and NSCH were compared using various experimental models. In rat aorta, NSCH and SCH made ...

      Abstract-In order to investigate the phamacological properties of New Wonbang Woohwangchungsimwon Pill (NSCH), effects of Wonbang Woohwangchungsimwon Pill (SCH) and NSCH were compared using various experimental models. In rat aorta, NSCH and SCH made the relaxation of blood vessels in maximum contractile response to phenylephrine (10^-6 M) regardless to endothelium containing or denuded rings of the rat aorta. Furthermore, the presence of the inhibitors of NO synthase and guanylate cyclase did not aftect significantly the relaxing effects of NSCH and SCH, NSCH and SCH inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs). NSCH and SCH decreased significantly heart rate. These, at high doses, had a negative inotropic effect that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In guinea-pig papillary muscle, these had no effects on parameters of action potential such as action potential amplitude (APA). V_max and resting membrane potential (RMP) at low doses, whereas inhibited the cardiac contractility at high doses. Furthermore, these had a significant inhibitory effects on palpitation of the heart in normotensive rats and SHRs. These results suggest that NSCH and SCH have weak cardiovascular effects, and that there is no significant differences between cardiovascular effects of two preparations.

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      목차 (Table of Contents)

      • 실험방법
      • 실험동물
      • 사용시료 및 시약
      • 실험방법
      • 흰쥐 흉부 대동맥에서의 이완반응
      • 실험방법
      • 실험동물
      • 사용시료 및 시약
      • 실험방법
      • 흰쥐 흉부 대동맥에서의 이완반응
      • 선천성 고혈압 쥐의 혈압과 심박동수에 미치는 영향
      • 심근수축력과 심혈류량에 대한 영향
      • 적출우심방의 심박수 및 수축력에 미치는 영향
      • 적출 유두근의 활동전위에 미치는 영향
      • 심계항진에 대한 효과
      • 실험결과
      • 흰쥐 흉부 대동맥에서의 이완반응
      • 선천성 고혈압 흰쥐의 대동맥에서 endothelium-de-rived contraction factor(DECF)에 미치는 영향
      • 선천성 고혈압 흰쥐의 혈압 및 심박동수에 미치는 영향
      • 심근수축력과 심혈류량에 대한 영향
      • 적출우심방의 심박수 및 수축력에 미치는 영향
      • 적출 유두근의 활동전위에 미치는 영향
      • 심계항진에 대한 효과
      • 고찰
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