Systemic Proteomics of Cellular Switch and Drug Development

다국어 초록 (Multilingual Abstract)

To understand cellular functional switch as a whole, one has to obtain comprehensive information on structure, activity, modification and interaction of all proteins involved in the related signaling and metabolic pathways. Such information could be acquired through large scale analysis of individual components as well as studies on correlation among associated components. Especially, for the development of disease-specific and effective new therapeutic drugs, comprehensive understanding of disease-related cellular system and structure-function relationship of protein families is required. To this end, our research group is generating and analyzing quantitative information on dynamic proteome fluctuation during disease-related cellular death phenomena that involves protein expression level, modification and subcellular localization changes. In relation to this analysis, we are also carrying out protein family-wide structure-function studies on disease related protein families such as protein tyrosine phosphatases and other target proteins identified from the proteome analysis. The structure-function data provide critical information on design of selective regulators of each enzyme. The systematic consideration of cellular regulation as exemplified in our studies would help to find effective strategies towards the development of next-generation therapeutic drugs.