Adenovirus 증식에 미치는 Hormone의 영향

다국어 초록 (Multilingual Abstract)

Approximately 40 separate adenoviruses have been isolated from man, Viruses in this group replicate in the nucle of infected cells and are of similar size (70-90 nm in diameter) and shape. All members appear to have a core cornposed of single molecule of DNA and common complement fixing structure virus antigen. Adenovirus infection in man produce acute pharygitis, tracheo bronchitis, bronchopneumonia or conjunctivitis. Several members of this group, including types commonly associated with respiratory disease in man, are capable of producing rnalignant tumors in young hamsters, and a few types have been shown to be oncogenic in young rats. Adenoviruses types 1, 2 and 5 have been recovered from surgically removed tonsil and adenoids and have been also associated with sporadic mild respiratory illness of infant and children. To obtain evidence concerning the effect of hormone on adenoviruses replication, investigation of 4 proto type viruses of this group was under taken. For practical consideration it was desirable to investigate of the effect of hormone (estradiol- 17B) on adenoviruses yields in L cells. Results were as follows: 1. Yields of adenovirus type 1, 4, 6, in L cell were inhibited by the treatment of estradiol-17B. 2. No significant effect of estradiol-17B was noted in productive system of adenovirus type 2.