The molecular basis of immune cell function : proceedings of the 13th International Leucocyte Culture Conference held in Ottawa, Canada, 22-25 May, 1979

목차 (Table of Contents)

• CONTENTS
• MAJOR PRESENTATIONS
• Introductory chapter
• Twenty years of culture and education：Has the lymphocyte become a good model for the study of cell proliferation? / J.G. Kaplan = 3
• Analysis of the proliferativee response
• The ionic hypothesis of cell activation at fertilization / R.A. Steinhardt ; M.M. Winkler = 11
• Can a fibroblast teach a lymphocyte anything useful? / V.G.H. Riddle ; P.W. Rossow ; R.J. Boorstein ; M.L. Addonizio ; A.B. Pardee = 29
• Cation fluxes and lymphocyte transformation / R. Hesketh = 39
• Studies of cyclic AMP metabolism in proliferating lymphocytes / J.E. Foker ; A.M. Malkinson ; J.R. Sheppard ; T. Wang = 57
• The calcium-induced, cyclic AMP-dependent initiation of DNA synthesis in thymic lymphoblasts and T51B liver cells / A.L. Boyntoh ; J. F. Whitfield = 75
• Membrane biochemistry
• The role of cell surface glycoproteins in lymphocyte activation / R.L. O'Brien ; J.W. Parker ; J.A. Frelinger ; J.F.P. Dixon ; M. L. Phillips ; I.L. Gordon = 87
• Glycoproteins of murine LPS blasts: Resolution and interactions / L. Cruz ; M. Letarte = 99
• The role of the plasma membrane in the initiation of lymphocyte activation / K. Resch = 109
• Lymphocyte actin and the nature of its interaction with the plasma membrane / B.H. Barber ; R.J. Allore = 127
• Regulation of immune cett function
• The kinetics and consequences of latent help to murine alloantigens / J. Knight ; A. Knight ; N.A. Mitchison = 139
• Circuits for regulating antibody responses / L.A. Herzenberg ; S.J. Black ; L.A. Herzenberg = 147
• Regulation of lymphocyte function by antiidiotype antibody / C. Bona = 161
• Clinical applications of leucocyte culture: The importance of cellular concentration / S.C. Knight ; B. Harding ; S. Burman ; J. O'Brien ; J. Farrant = 181
• Tolerance as a probe for age dependent changes of the immune system / B. Cinader ; K. Nakano = 193
• T-cell differentiation and profiferation
• Complexity within T lymphocytes responding in primary and secondary in vitro reactions / F.H. Bach ; B.J. Alter ; M.L. Sopori = 209
• The role of soluble factors in the regulation of T-cell immune reactivity / K.A. Smith ; S. Gillis ; P.E. Baker = 223
• T cell mitogenic factor and human cultured T cells as valuable immunological reagents / G.D. Bonnard ; K. Yasaka ; D.J. Schendel ; F. Pappas ; R.D. Maca ; J.M. Alvarez ; D.M. Strong ; N.P- Lan ; R. Fagnani ; N. Navarro ; F. Pandolfi = 239
• Growth characteristics and functional analysis of human T-cell colonies / E.W. Gelfand ; H.-M. Dosch ; J.W.W. Lee ; R. Schuurman ; G. Price = 249
• Adherent and accessory cells
• Host-defense by and self-defense of phagocytic leukocytes / J D. Roos ; R.S. Weening ; A.A. Voetman = 259
• Dendritic cells: An important new cell type in the mixed leukocyte reaction / R.M. Steinman ; M.D. Witmer ; M.C. Nussenzweig ; L.L. Chen ; Z.A. Conn = 273
• $$F_c$$ receptors in immune regulation
• Immunoregulatory function of $$F_c$$ receptors in B Iymphocyte responses / M.F. La Via ; J.K.A. Nicholson ; D.S. La Via = 283
• Suppression
• The use of conjugates of allergens with synthetic polymers for suppression of IgE antibodies / A.H. Sehon ; W.Y. Lee = 293
• Proliferation and defective function of lymphoid cells in African trypanosomiasis / D.L. Sacks ; B.A. Askonas = 305
• Hybrzdomas and monoolonal antibodies
• Monoclonal antibodies and the fluorescence-activated cell sorter: Complementary tools in lymphoid cell biology / L.A. Herzenberg ; J.A. Ledbetter = 315
• Hybridomas as a tool for the analysis of antibody diversity / G. Buttin ; D. Juy ; L. Medrano ; P. Legrain ; C. Leguern ; P.A. Cazenave = 331
• Characterization of hybridoma and mononuclear cell clones / D.D. Eckels ; M.E. Gershwin = 343
• COMMUNICATIONS
• Cytoskeleton
• Colchicine inhibits the early enhancement of $$［^{3H}$$］uridine incorporation in lymphocytes activated by high concentrations of concanavalin-A / D.R. Forsdyke = 355
• Role of microtubules in modulating the stimulatory activity of cell-surface la antigens / D.F. Ranney ; J.P.Y. Ting = 361
• Colchicine inhibites lymphocyte transformation both prior to and after commitment / C.E. Rudd ; J.G. Kaplan = 364
• Immunofluorescent assay of colchicine effects on lymphocyte microtubules / K.A. Rogers ; D.L. Brown = 368
• α-actinin is associated with mouse lymphocyte plasma membrane and cocaps with surface immunoglobulins and Thy-1 antigen / D. Hoessli ; E. Rungger-Braendle ; G. Gabbiani = 372
• Prostaglandins
• Stimulation of prostaglandin production and its effect on lymphoid cell function during the graft-versus-host reaction / W.S. Lapp ; H. Kirchner ; D. Gemsa = 376
• Effects of prostaglandin $$E_1$$ （PG$$E_1$$） on murine lymphocytes / A. Winkelstein ; V.E. Ketley ; R.A Silva = 379
• Differences in immune responsiveness: Comparison with sex and age / M.M. Rosenstein ; HR. Strausser = 383
• Membrane receptors
• Occupancy dependent affinity in the leukoagglutinin lymphocyte model / G.B. Faguet = 387
• Isolation of an IgG receptor from human T lymphocytes and production of a heteroantiserum / C. Cunningham-Rundles ; D. Lawless ; S. Gupta ; C. Galanos ; R.A. Good = 391
• High molecular weight differentiation markers on the surface of T lymphocytes / D. Hoessli ; P. Vassalli = 395
• Cations；Cell volume
• Lymphocyte sodium concentration regulates monovalent cation transport after PHA stimulation / G.B. Segel ; M.A. Lichtman = 399
• Con A enhancement of ouabain-sensitive rubidium fluxes in mouse splenocytes - Effects of amiloride and furosemide / T. Owens ; J.G. Kaplan = 402
• The potential for artifact in ion determinations in lectin - treated lymphocytes / W. Negendank ; C. Shaller = 406
• Modulation of lymphocyte activation by LiCl / D.A. Hart = 408
• The effect of tin on unscheduled and semi-conservative DNA synthesis / J.R. McLean ; J.G. Kaplan = 412
• Total and exchangeable calcium in mitogen-treated lymphocytes / A. Lichtman ; G.B. Segel ; M.A ; Lichtman = 417
• The role of exogenous C$$a^{++}$$ on the stimulation of lymphocytes by mitogens / A.J. Ulmer ; H.D. Flad ; T. Diamantstein = 420
• The cellular volume changes of viable cells during mitogenic-stimulation of rat lymphocytes / J.H. LaBadie ; C.F. Beyer ; E.H. Harrison ; R.N. Mitchell ; W.E. Bowers = 423
• Biochemistry: Ensymes and metabolism
• Role of adenosine transport in lymphocyte stimulation / J. Dornand ; J-C. Bonnafous ; J-C. Mani = 426
• Further characterization of the thymidihe-containing macromolecular material from mouse spleen cell surface / P.P. Strauss ; V.L. Ecker ; E. Supple = 429
• The translatability of purified cytoplasmic poly($$A^+$$) RNA from resting and PHA-activated pig lyrnphocytes / D.M. Wallace ; J.E. Kay = 432
• Acyltransferase inhibition by lectins is related to hydrophobicity / P. Dobson ; A. Mellors = 436
• Mechanism of T lymphocyte "deletion" by high concentration of ligand （Concanavalin A） / M. Takigawa ; B.H. Waksman = 439
• The effect of therapeutic ultrasound on DNA synthesis in human lymphocytes / M.H. Repacholi ; J.G. Kaplan ; J. Little = 443
• Proteases and complement
• Effect of proteases on the early events of in vitro AFC response / J. Stein-Streilein ; D.A. Hart = 447
• Killing by murine cytotoxic T lymphocytes: Involvement of thiols and proteases / D. Redelman ; D. Hudig = 451
• The participation of the outer cell membrane in the killing of E. cot-i by human polymorphonuclear leucocytes （PHN） / J. Menzel ; H. Bannert ; H. Zentgraf = 454
• Biosynthesis and secretion of plasminogen activatdr by thioglycollate-elicited macrophages / J.C. Drapier ; G. Lemaire ; J.P. Tenu ; J.F. Petit = 458
• The guinea pig complement activating surface marker （GPCA） : Functional evidence for its characteristic prescence on murine T lymphocytes / F. Kierszenbaum ; D.B. Budzko = 462
• A possible role for complement in lymphocyte activation / J. S. Sundsmo ; J.K. Selberg ; A.C. Chin ; O. G$$\ddot o$$tze = 466
• C2 deficiency. Description of linkage of HLA-A25, B18, C$$2^o$$with Dw2 GL01 and with D unknown, GL02 / M.L. Mahowald ; A.P. Dalmasso ; R.A. Petzel ; E.J. Yunis = 471
• Immunobiology of Fc receptors induced by human herpesviruses in lymphoid cells / A.E. Bourkas ; J. Menezes = 475
• Mitogens: Activation and modulation
• Lymphocyte colony formation in agar: 2-mercaptoethanol can be substituted by 2-mercaptoethanol activated serum albumin / H.D. Flad ; A.J. Ulmer ; M.H. Claesson ; H.-G. Opitz = 479
• Synergy between polyclonal B cell activators and soluble sheep red blood cell antigens in the SRBC-specific plaque forming cell response of human peripheral blood / B lymphocytes ; D. Volkman ; A.S. Fauci = 483
• Pokeweed mitogen responsiveness of human neonatal lymphocytes / P.E. Lipsky ; Z.T.V. Dugan = 487
• Study of regulation of the secondary antibody response in mice using endotoxin as a cellular probe / S.M. Walker ; W.O. Weigle = 491
• Potentiation of mitogen stimulated T lymphocyte proliferation by an antiserum to human lambda light chains / E. Kondracki = 495
• Maturation of nu／nu mouse spleen pre-T cells induced "in vitro" by muramyl dipeptide / M. Fevrier ; C. Duquenne ; J.L. Birrien ; P. Liacopoulos = 499
• Response to microbial agents
• Mitogenic bacterial surface components : B-lymphocyte stimulatory activity in vitro of protein 1 from the outer membrane of Escherichia coli / W. Bessler ; U. Henning = 503
• Viral activation of suppressor lymphocytes following membrane-membrane interaction : Induction of a lymphocyte-directed inhibitor （LDI） of mitogenesis / E. Israel ; B. Beiss ; M.A. Wainberg = 507
• Mixed lymphocyte reaction （MLR）
• Lymphocyte activating determinants （LADS） on null and T cells / L. Fainboim ; D. Jaraquemada ; H. Festenstein ; M. Greaves = 511
• Macrophage are the primary stimulators of the autologous mixed lymphocyte response （MLR） in man / M. Beale ; R. MacDermott ; M. Stacey ; G. Nash ; B. Hahn ; M. Seiden ; S. Burkholder = 515
• Lymphocyte proliferation kinetics in mixed lymphocyte cultures / C.C. Stewart ; B. Hamill = 518
• Relationships shown by in vitro secondary "PLT" response to hapten modified cells in dinitrochlorobenzene sensitive humans / W.R. Levis ; A.M. Dattner ; D.L. Mann = 522
• Potentiation of allospecific cytotoxic T cell development by the autologous MLR / N.M. Ponzio ; L.A. Matteoni ; J.M. Sarley = 525
• Major "histocompatibitity complex - Immunogenetics
• Roles of HLA-DR and HLA-D antigens in haplotype-primed LD typing reagents / N.L. Reinsmoen ; H.J. Noreen ; T. Sasazuki ; M. Segall ; F.H. Bach = 529
• Responses of thymocytes to alloantigenic stimuli / M. Sopori ; F. Bach = 534
• The role of Ia-bearing accessory cells in T cell-mediated and T cell-dependent responses / G. B. Ahmann ; A. Birnkrant ; C.B. Pettinelli ; P. Nadler ; D.H. Sachs ; R.J. Hodes = 538
• Idiotypic network : Maternal and neonatally-induced effects on clonal expression / J.C. Olson ; G.A. Leslie = 542
• Transplantation, graft versus host
• In vitro chemotaxis of lymphocytes to fluid factors in rejecting allografts / R. Hoffman ; N. Ascher ; R.L. Simmons = 545
• In vitro study of the effects of the GVH reaction on T cell immunocompetence / M. Seddik ; T.A. Seemayer ; W.S. Lapp = 549
• Target cells lysis ; natural killer cells
• Generation of tumor cytostatic macrophages by ascites of tumor-bearing mice / D. Gemsa ; W. Kramer ; G. Till ; K. Resch = 552
• Correlation between pre-transplant natural killer cell activity （HSV-1） and the subsequent development of GVH following marrow and fetal liver transplant / C. Ching ; D. Kirkpatrick ; M. Sorell ; C. Lopez = 555
• Generation of CML negativity after planned blood trans-fusion in renal allograft recipients / E. Goulmy ; E. Blokland ; G.G. Persijn ; B.A. Bradley ; J.J.van Rood = 560
• Specific conjugation of enucleated cytotoxic T lymphocytes with target cells / Y. Kaufmann ; G. Berke = 564
• Human T lymphocyte-mediated, antibody-dependent cytotoxicity / B.S. Handwerger ; D. Giroux ; N.E. Kay ; B. Goodspeed ; S. Hatfield ; J.R. Schmidtke = 568
• Induction of specific secondary cytolytic activity by treatment of human memory cells with mitogenic oxidizing agents / M. Suthanthiran ; K.H. Stenzel ; A.L. Rubin ; A. Novogrodsky = 572
• The 'relationship between NK and K cells / P.J. Jensen and H.S. Keren = 574
• Spontaneous human lymphocyte-mediated cytotoxicity against tumour target cells. VIII. Characteristics of normal lymphocytes showing consistently high or low natural killer （NK） cell activity / H.F. Pross ; K. Wilberforce ; D. Dean ; J.C. Kennedy ; M.G. Baines = 580
• The identity of the naturally-occurring cytotoxic cells in man / M. Richter ; D. Banerjee ; L. Fernando ; S. Sklar = 585
• NK-cell cytotoxicity is performed by promonocytes, which are isolated from mouse bone-marrow cultures / M.L. Lohmann-Matthes ; W. Domzig = 588
• Tumor - immunology
• Tone of concanavalin A activated suppressor cells in patients with malignancies / C. Hammer ; L.M. Jerry ; M.G. Lewis = 591
• Induction of tumor regression by a factor in tumor ascites / J.-F. Kapp ; K. Eichmann = 594
• Comparison of the immunomodulatory effects of three different strains of BCG on antibody formation ; mitogen responsiveness and induction of immune interferon / K. Huygen ; J. Content ; M. Weckx ; L. Thiry = 598
• Imbalance of T cell subsets and abnormal locomotion of T cells in adult untreated Hodgkin's disease / S. Gupta ; R. Schulof ; B. Lee ; M. Lacher ; D. Straus ; B. Clarkson ; R. Good = 601
• Differential analysis of spontaneous uptake of thymidine and transferrin by mononuclear cells in vitro in Hodgkin's disease / S. Cunningham-Rundles ; M. de Sousa ; B. Dupont ; J.J. Bognacki ; J.A. Garofalo ; B. Lee ; R.A. Good = 605
• Biophysical differentiation of blood lymphocytes ; applying the fluorescence polarization methodology （SCM） ; for the diagnosis of malignancy / N.D. Schnuda = 609
• Lymphocyte subpoputations
• Toward the cloning of T lymphocyte / B.J. Alter ; J.A. Hank ; H. Inouye ; F.H. Bach = 614
• Continuously growing human T lymphocytes derived from allogeneically primed cultures: A comparison of immune reactivities expressed by cells maintained with lectins or conditioned medium / D. Charmot ; B. Malissen ; C. Mawas = 618
• Study of murine T lymphocyte subpopulations by use of peanut agglutinin / J. London ; S. Berrih ; B. Bonavida ; M. Horton = 623
• Fractionation of human peripheral blood lymphocytes （PBL） with plant lectins / D.H. Boldt ; R.D. Lyons = 627
• Separation of human T lymphocyte subpopulations ($$T_μ$$ ; $$T_γ$$ and $$T_α$$) by density gradient electrophoresis / C.D. Platsoucas ; R.A. Good ; S. Gupta = 631
• Sex-associated differences in histamine receptor bearing human lymphocyte subsets / B. Tartakovsky ; S. Segal ; A. Shani ; S. Hallerstein ; Y. Weinstein ; Z. Bentwich = 634
• Macrophages
• Circulating monocytes suppress the Nocardia water soluble mitogen （NWSM）-induced blastogenic response of human lymphocytes / A. Dimitriu = 638
• Effect of anti HLA antisera on macrophage T cell interaction / R.S. Geha ; H.F. Milgrom ; M. Broff ; S. Alpert ; S.Martin ; E.J. Yunis = 642
• Differentiation
• Basophil production in the guinea pig : Requirements for antigen ; splenic T-cells and bone marrow precursors / J.A. Denburg ; J.Bienenstock = 646
• Limiting factors in T helper cell differentiation / E.F. Potworowski ; L. Zollinger ; J. Teodorczyk-Injeyan = 650
• Identification of the prethymic precursor T-cell in normal bone marrow / S. Limatibul ; H.-M. Dosch ; A. Shore ; E.W. Gelfand = 654
• Cell-cell-interaction
• Interaction of accessory cells and lymphocytes involved in response to the T cell mitogens : Sodium periodate, neuroaminidase plus galactose oxidase, and concanavalin A / W.E. Bowers ; C.F. Beyer = 658
• Contact cooperation in T lymphocyte mitogenesis: Auto-catalytical system of mutual interactions between macro-phages and lymphocytes / J.H. Peters ; L. Schimmelpfeng = 660
• T cell regulation of immunoglobulin production by B-lymphoblastoid cell lines / D.H. Kempner ; R.A. Gatti = 664
• Anti-IgD activated B-cells enhance antigen responses of T-cells / M.A. Cuchens ; D.R. Burger ; G.A. Leslie = 668
• Suppression and suppressor cells
• Adult thymectomy and cyclophosphamide have selective effects on immunoregulatory T cells and their precursors / M.M. Sigel ; R.D. Paul ; A. Ghaffar = 671
• Analysis of an immunoregulatory suppressor T cell system in newborn mice / D.C. Hooper ; T.L. Delovitch ; H. Wigzell ; R.A. Murgita = 676
• B lymphocyte colony suppression in vitro : Characteristics of the suppressor cell / M.H. Cla$$\ddot e$$sson = 680
• OVA specific T cell hybrids / R.B. Whitaker ; N.H. Ruddle = 684
• Soluble factors and mediators
• High and low producers of the "PHA-induced stimulating" factor acting on T cell growth / D. Fradelizi ; M. Sasportes ; G. Cathely ; E.E. Wollman ; D. Cohen ; E. Carosella ; J. Dausset = 688
• Suppression of the allogeneic response in humans : Suppressor T lymphocytes produce a soluble suppressor factor / M. Sasportes ; D. Fradelizi ; D. Cohen ; E.E. Wollman ; E. Carosella ; G. Cathely ; J. Dausset = 692
• Suppressor cells and macrophage migration / R.A. Fox ; K. Rajaraman = 696
• Regulation of the production of lectin induced mitogenic factor （LMF） by human T lymphocytes / H. Northoff ; J.J. Oppenheim = 700
• Interferon production in the murine mixed lymphocyte culture / R. Zawatzky ; H. Becker ; H. Engler ; V. Schirrmacher ; H. Kirchner = 704
• Auto-immunity, clinical
• Impaired neutrophil chemotaxis and lymphocyte capping in patients with myotonic muscular dystrophy / M. Rola-Pleszczynski ; P. Walton ; B. Lemieux = 707
• Antibodies produced to homologous lens crystallin following traumatic lens injury / L. Goldschmidt ; S.M. Walker ; W.O. Weigle = 711
• The induction of autoantibodies in vivo / L.B. Pancer ; D.A. Bell ; S.K Singhal = 715
• Lymphocyte subpopulations in congenitally immunologic mutant New Zealand mice / Y. Ohsugi ; M.E. Gershwin = 719
• WORKSHOP REPORTS
• Nucleic acid and protein synthesis / K.P. Sch$$\ddot a$$fer ; M. Mitchell = 725
• Biochemistry : Metabolism and enzymes / J.-C. Mani ; J. Dornand = 728
• Cations / M.A. Lichtman ; G.B. Segel = 732
• Cytoskeleton - colchicine / D.L. Brown = 734
• Lymphocyte activation / M.R. Quastel ; A. Novogrodsky = 737
• Membrane receptors / C. Cunningham-Rundles ; G.B. Faguet = 739
• Hybridomas / M.E. Gershwin = 742
• Soluble factors and mediators / G.D. Bonnard ; J.L. McCoy = 744
• Continued cultures of T cells / G.D. Bonnard = 746
• Serum factors ; Complement ; Proteases / D.R. Forsdyke = 748
• Mixed leucocyte reaction - （MLR） / W.R. Levis ; A.S. Coulson = 749
• MHC / B.J. Alter ; M. Segall = 751
• Graft versus host / W.S. Lapp = 753
• Target cell lysis / B.S. Handwerger = 755
• Tumor immunology / L.M. Jerry = 759
• Macrophage-granulocytes / A. Dimitriu ; D. Roos = 761
• Differentiation, ontogeny / E.F. Potworowski ; L. Lafleur = 764
• Cell cooperation / W.E. Bowers 766
• Suppressor cells / M.M. Sigel = 767
• Parasite immunology / P. Wright = 771
• Clinical immunology - Auto-immunity / M. Rola-Pleszczynski = 773
• Author index = 777