The role of BF-7 on Neuroprotection and Enhancement of Cognitive Function

다국어 초록 (Multilingual Abstract)

Amyloid β-peptide (Aβ) contributes to the pathogenesis of Alzheimer's disease (AD), causing neuronal death through apoptosis. In this study, the neuroprotective role of BF-7, extracted form sericultural product, was examined against Aβ -induced toxicity in cultured human neuronal cell SKN-SH. In order to know if the BF-7 has positive role on the cognition and memory in human, the mixture of BF-7, DHA and EPA (BDE) was examined using Rey Kim and K-WAIS test with 50 healthy high school student. We report here that BDE significantly attenuated Aβ-induced apoptosis through the reduction of ROS accumulation, and diminished caspase-like protease activity. Moreover, the memory index and memory preservation, and attentative concentration of BDE treated group for 1 month were significantly improved, in contrast to the case of placebo control treated with DHA and EPA. This result represent that the BF-7 play significant positive role on learning memory. Taken together, our result suggested the natural product BF-7 is a good substance for the brain functionally and physiologically.

참고문헌 (Reference)

1 "β-Sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis:implications for Alzheimer's therapy" 4 : 822-826, 1998

2 "mediated damage to NADPH-diaphorase containing neurons is Ca2+ dependant" 93-96, 1994

3 "beta-Amyloid (1-40)-induced apoptosis of cultured cortical neurones involves calpain-mediated cleavage of poly-ADP-ribose polymerase" 24 : 179-186, 2003

4 "Vitamin E protects nerve cells from amyloid toxicity" 944-950, 1992

5 "The acute neurotoxic effect of β-amyloid on mature cultures of rat hippocampal neurons is attenuated by the anti-oxidant U-78517F" 79 : 185-190, 1994

6 "Staurosporin and K-252 compounds protect hippocampal neurons against amyloid β-peptide toxicity and oxidative injury" 650 : 170-174, 1994

7 "Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a β-sheet breaker peptide" 16 : 860-862, 2002

8 "Oxidative neurotoxicity in rat cerebral cortex neurons:synergistic effects of H2O2 and NO on apoptosis involving activation of p38 mitogen-activated protein kinase and caspase-3" 72 : 508-519, 2003

9 "Neurotrophic factors protect terminals against amyloid- and oxidative stress-induced impairment of glucose transport, glutamate transport and mitochondrial function" 10 : 50-57, 2000

10 "Neuropsychiatric aspects of Alzheimer's disease:the cholinergic hypothesis revisited" 47 : 876-883, 1996

11 "Nerve growth factor prevents 1-methyl-4- penyl-1,2,3,6- tetrahydropyridine-induced cell death via the Akt athway by suppressing caspase-3-like activity using PC12 cells relevance to therapeutical application for Parkinson's disease" 63 : 402-409, 2001

12 "Mechanisms of neuronal degeneration in Alzheimer's disease" 16 : 921-932, 1996

13 "Marine oils as a source of omega-3 fatty acids in the diet how to optimize the health benefits"

14 "Involvement of oxidative stress- induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease" 101 : 2070-2075, 2004

15 "Effects of transdermal nicotine on attention and memory in healthy elderly non-smokers" 159 : 83-88, 2001

16 "Cellular actions of β-amyloid precursor protein and its soluble and fibrillogenic derivates" 77 : 1081-1132, 1997

17 "Caspase-dependent apoptotic pathways in CNS injury" 24 : 131-144, 2001

18 "Aberrant sphingomyelin/ ceramide metabolic- induced neuronal endosomal/lysosomal dysfunction:potential pathological consequences in age-related neurodegeneration" 55 : 1515-1524, 2003

19 "AMPA/kainate receptor-"