유암의 새로운 예후인자들의 임상적 의의 = Clinical Significance of New Prognostic Factors in Breast Cancer

국문 초록 (Abstract)

유암예후에 영향을 미치는 전통적 3인자로 종양의 크기, 전이액와임파절의 수 및 menopausal status를 들 수 있고, 이 외에 최근에는 면역학과 분자생물학의 비약적 발달로 호르몬 수용체, DNA ploidy, cathepsin D, pS2 protein 및 다양한 oncogene들의 증폭이나 과발현 등이 새로운 독립적 예 후인자로 보고되고 있다. 저자들은 유암 110례의 10년 추적조사 성적을 기반으로 이들 새로운 예후인자중 c-erbB-2 oncoprotein, cathepsin D 및 pS2 protein의 과발현이 전통적 예후인자들과 상관성이 있는지와 독립적 예후인자로서 의의가 있는지를 확인하고자 본 연구에 착수하였다.

다국어 초록 (Multilingual Abstract)

This study was undertaken to define the prognostic value of the overexpression of c-erbB-2 oncoprotein, cathepsin D and pS2 protein in 40 breast cancer patients.
The results were as follows :
1.Overall, 32% of patients were positive for c-erbB-2 oncoprotein. Positive staining correlated with menopause status, tumor size and TNM staging, but not wish axllary nodal status. Although there was apparent difference in cumulative survival rates between positive-and negative-staining groups, it was not statistically significant(p=0.0625).
2.52.5% of patients were positive for cathepsin D. Positive staining did not correlate with menopause status, axillary nodal status or tumor size. There was no statistical difference in cumulative survival rates between positive-and negative-staining groups of cathepsin D.
3.57.5% of patients were positive for pS2 protein. Positive staining did not correlate with menopause status, axillary nodal status, tumor size or tumor stage. There was no statistical difference in cumulative survival rates between positive-and negative-staining groups of pS2 protein.

목차 (Table of Contents)

• Ⅰ.서론
• Ⅱ.재료 및 방법
• 1.연구 대상
• 2.면역조직학적 검사방법
• 3.통계처리방법
• Ⅲ.결과
• Ⅳ.고안
• Ⅴ.결론