새로 국내에서 밝혀진 균주(R19)와 전통적 균주를 이용하여 혈청학적으로 진단된 쯔쯔가무시병의 임상상 및 항체반응 양상 = The Antibody Responses to Newly Isolated Strain(R19) in Korea & Three Major Serotypes and Clinical Features of Tsutsugamushi Disease

다국어 초록 (Multilingual Abstract)

From September to December 1989, eighteen cases of tsutsugamushi disease were diagnosed by indirect immunofluorescent antibody test in Ulsan-Ulchu area. Their clinical features and patterns of antibody response to R. tsutsugamuschi were analyzed. It was most prevailing in female over 30 years old. Most of patients (16 patients) were rural inhabitants. Two patients in urban area had reaped the rice in the rice field at several days before onset of the disease. It occurred between September and November with a peak in October. Chief complaints of patients were febrile sensation with or without chills or headache. All patients had fever and chills. Headache and myalgia were common. In one patient, delirium with visual hallucination was seen. The major physical findings were skin rash (83%), eschr (78%), lymphadenopathy (11%). The skin rash appeared on whole body or on the trunk. The eschar appeared on the chest or abdomen or in the genial region.
The antobody titer to R 19 that had been newly isolated strain in Korea was universally high. There often were anemia (31%), leukocytosis (23%). Microscopic hematuria and pyuria were also seen in routine urinalysis. Liver function tests showed eleveted aminotransferases and LDH. There were erythrophagocytic histiocytes in the bone marrows of six patients among the ten patients whose bone marrow had been aspirated. Chloramphenicol had been used in all patients. The mean time to alleviation of fever was 2.5 days. All patients were cured.