클라리스로마이신의 건강한 한국 성인에 대한 집단 약물동태 = Population Pharmacokinetics of Clarithromycin in Healthy Adult Korean

다국어 초록 (Multilingual Abstract)

The purpose of this study was to estimate the population pharmacokinetics of clarithromycin in healthy adult Korean and to investigate the factors if1uencing the pharmacokinetics of clarithromycin. The population pharmacokinetic parameters of clarithromycin were calculated with the data from healthy adult Koreans. A total of 798 plasma concentrations obtained from 78 subjects after administration of a single oral dose of 250 mg or 500 mg were used for the modeling. The concentration-time data were fitted to a one-compartment open model assuming a first-order absorption and elimination with no lag time. The correlations between various factors [such as sex, age, height, welght, serum creatinine (Scr) and dose ] and pharmacokinetic parameters were estimated with stepwise linear regression analyses. The selected covariates were incorporated in the population model of NONMEM, and the importance of each covariate was investigated by means of backwards elimination. The apparent clearance (CL/F) was significantly correlated to Scr and sex, and the apparent volume of distribution (Vd/F) was significantly correlated to Scr and height in a nonlinear relationship. The population values of Ka was 1.8 hr-1, CL/F was 37.71 L/hr Vd/F was 200 L and t1/2 was 3.68 hrs for a male Korean with 170 cm height and 1.0 mg/dL Scr.