국소 신경학적 장애가 동반되지 않은 급성 뇌중풍 환자에서S-100B 단백의 유용성|RISS 상세보기

다국어 초록 (Multilingual Abstract)

Purpose: There is a distinct probability of severe complications
with stroke unless patients are administered proper
treatment at the optimal time. S-100B protein has been
reported to be elevated in brain injuries. The current study
investigates the efficacy of serum S-100B protein administration
during the diagnostic process for patients who have
had an acute stroke.
Methods: We prospectively recruited the patients with nonspecific
neurological symptoms. Non-specific neurological
symptoms were defined as no focal neurological deficits or
stroke suspected symptoms with NIHSS score zero. We
grouped the patients according to the presence of a brain
lesion (positive vs negative group) by computed tomography
or magnetic resonance imaging. Using serum S-100B
protein together with CT/MRI imaging at the time of diagnosis,
the cutoff value, sensitivities, and specificities were calculated
in making a diagnosis of acute stroke.
Results: Thirty one patients were enrolled. The level of
serum S-100B protein was higher in positive group (median
0.201, interquartile range 0.134-0.469) than in negative
group (0.085, 0.060-0.106, p=0.001). In diagnosing acute
stroke, the sensitivity was 90.9% at a cutoff value for serum
S-100B protein of 0.10 μg/L . At the cutoff level of serum S-
100B protein and the specificity was 75.0%.
Conclusion: The current results suggest that serum S-
100B protein may be a useful serologic marker for detecting
acute stroke that is suspected with non-specific neurological
abnormalities. Further studies are necessary to use the
marker as a screening method for acute strokes.

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참고문헌 (Reference)

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