Trinitrobenzene Sulfonic Acid에 의해 유발된 백서의 대장염에서 항염증제제의 치료효과 = The Effect of Anti-Inflammatory Drugs on Colitis Induced by Trinitrobenzene Sulfonic Acid in RatsTrinitrobenzene Sulfonic Acid에 의해 유발된 백서의 대장염에서 항염증제제의 치료효과

다국어 초록 (Multilingual Abstract)

Background/Aims: The causes and pathogenesis of inflammatory bowel disease remain unknown and no definite therapy exists until now. In order to clarify the effect of Artemisia capillaris, colitis was induced by trinitrobenzene sulfonic acid(TNBS) in rats, and the effect of anti-inflammatory drugs and Artemisia capillaris was compared. Methods: Wel]-grown Sprague-Dawley rats were divided into 7 groups and colitis was induced by TNBS except the control group. Each group was treated with 1% methyl ce]lulose, prednisolone l mg/kg, sulfasalazine 100 mg/kg, prednisolone and sulfasalazine, A.capillaris 1 mg/kg and 10 mg/kg per oral route from the next day. After 2 weeks, rats were sacrificed and gross morphologic features of colons were examined. Resullts: Ulceration, adhesion, thickening and dilatation were noticed in the colonic mucosa after TNHS insti]lation. Adhesion, thickening and di]atation were significantly improved in all the treated groups, but the ulceration was significantly improved only in groups treated by prednisolone and A.capillaris 10mg/kg. Conclusions: The colitis induced by TNBS is sirnilar to the human inflammatory bowel disease and the prednisolone and A.capillaris have a healing effect on rat colitis induced by TNBS. (Korean J Gastroenterol 1996; 2S:224 - 231)