고혈압 전단계 여성에 대한 골격근 group Ⅲ 기계적 수용기 자극 시 심혈관에 미치는 영향 = Group Ⅲ Muscle Afferent Mechanoreflex is Altered in Prehypertensive Women

다국어 초록 (Multilingual Abstract)

It was suggested that the exercise pressor reflex (EPR) plays an important role to regulate the cardiovascular responses during dynamic exercise. A component of EPR, group Ⅲ mechanoreceptors evoked excessive blood pressure response in hypertensive rats during passive tendon stretch. But it is not known that this exaggerated blood pressure response to passive tendon stretch is mediated by EPR overactivity in prehypertensive women. Therefore, this study was to investigate the physiological responses in both normotension and prehypertension during passive tendon stretch. Twenty subjects (10 prehypertension and 10 normotension) with a mean age 49.0±3.4 years were recruited for this study. All subjects were continuously instrumented to measure stroke volume (SV), heart rate (HR), cardiac output (CO), total vascular conductance (TVC) throughout the experiment. To stimulate the group Ⅲ mechanoreceptors, brief passive dorsiflexion of the foot was performed by a cybex for one minute. The results showed that mean arterial blood pressure was significantly increased during dorsiflexion in both groups, however, this pressor response was significantly higher in prehypertensive women. SV and CO were significantly increased in normotensive women, while there were no differences in prehyperentsive women. There was no difference in HR in both groups. TVC was significantly decreased in prehypertension, while no difference in normotension. It is concluded that the excessive pressor response mediated by dorsiflexion is occurred by overactivity of group Ⅲ mechanorecptors and the mechanism is produced via mainly peripheral vasoconstriction in prehypertensive women.

목차 (Table of Contents)

• Abstract
• 1. 서론
• 2. 연구방법
• 3. 결과
• 4. 논의
• 5. 결론
• 후기
• 인용문헌

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