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      KCI등재

      건강기능성 식품소재로서 pinitol의 특성

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      https://www.riss.kr/link?id=A76310093

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      다국어 초록 (Multilingual Abstract)

      D-pinitol, another chemical structure of 3-O-methyl-D-chiro-inositol, is an important insulin-sensitizer. The purpose of this review is to examine the characteristics of pinitol and other analogs as functional food biomaterials which were well known to reduce blood glucose levels. Pinitol can be converted to chiro-inositol in normal humans, while diabetic patients can not use the molecule, resulting in exhibiting low level of chiro-inositol in their urine. Recently, it is reported that pinitol can trigger phospholipase C/D, thus the rate of glucose metabolism accelerates to use as fuel for human body. To not only reduce insulin resistance of diabetic patients, but also alleviate the symptoms of diabetes, obesity, and muscle contraction, pinitol and its dietary supplementation is needed.
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      D-pinitol, another chemical structure of 3-O-methyl-D-chiro-inositol, is an important insulin-sensitizer. The purpose of this review is to examine the characteristics of pinitol and other analogs as functional food biomaterials which were well known t...

      D-pinitol, another chemical structure of 3-O-methyl-D-chiro-inositol, is an important insulin-sensitizer. The purpose of this review is to examine the characteristics of pinitol and other analogs as functional food biomaterials which were well known to reduce blood glucose levels. Pinitol can be converted to chiro-inositol in normal humans, while diabetic patients can not use the molecule, resulting in exhibiting low level of chiro-inositol in their urine. Recently, it is reported that pinitol can trigger phospholipase C/D, thus the rate of glucose metabolism accelerates to use as fuel for human body. To not only reduce insulin resistance of diabetic patients, but also alleviate the symptoms of diabetes, obesity, and muscle contraction, pinitol and its dietary supplementation is needed.

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      목차 (Table of Contents)

      • 대사증후군으로서 당뇨
      • Pinitol의 특성 및 기능
      • Pinitol의 이용
      • 감사의 글
      • References
      • 대사증후군으로서 당뇨
      • Pinitol의 특성 및 기능
      • Pinitol의 이용
      • 감사의 글
      • References
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      참고문헌 (Reference)

      1 김미진, "혈당조절이 불량한 제2형 당뇨병환자에서 Pinitol 투여가 당 대사 및 아디포사이토카인에 미치는 효과" 대한당뇨병학회 29 (29): 344-351, 2005

      2 박지영, "키토산과 히비스커스 추출물, L-카르니틴 함유 식이가 흰쥐의 체중과 지질대사에 미치는 영향" 한국식생활문화학회 20 (20): 195-6, 2005

      3 Suzuki, S., "Urinary chiro-inositol excretion is an index marker of insulin sensitivity in Japanese type II diabetes" 17 : 1465-1468, 1994

      4 Sohn, J. E., "The effect of pinitol supplementation and resistance exercise on blood glucose level, physical characteristics, and physical fitness in elderly" 9 : 189-194, 2005

      5 Viollet, B., "Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders" 33 : 395-402, 2007

      6 Zhan, T., "Synthesis of azole nucleoside analogues of D-pinitol as potential antitumor agents" 342 : 865-869, 2007

      7 Sia,C., "Spotlight on ethnomedicine: Usability of Sutherlandia flutescens in the treatment of diabetes" 1 : 145-149, 2004

      8 Kipfer-Coudreau, S. D., "Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects" 47 : 1278-1284, 2004

      9 Larner, J., "Rat liver insulin mediator which stimulates pyruvate dehydrogenase phosphatase contains galac- tosamine and D-chiroinositol" 151 : 1416-1426, 1988

      10 Gu, F., "Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress" 279 : 49689-49693, 2004

      1 김미진, "혈당조절이 불량한 제2형 당뇨병환자에서 Pinitol 투여가 당 대사 및 아디포사이토카인에 미치는 효과" 대한당뇨병학회 29 (29): 344-351, 2005

      2 박지영, "키토산과 히비스커스 추출물, L-카르니틴 함유 식이가 흰쥐의 체중과 지질대사에 미치는 영향" 한국식생활문화학회 20 (20): 195-6, 2005

      3 Suzuki, S., "Urinary chiro-inositol excretion is an index marker of insulin sensitivity in Japanese type II diabetes" 17 : 1465-1468, 1994

      4 Sohn, J. E., "The effect of pinitol supplementation and resistance exercise on blood glucose level, physical characteristics, and physical fitness in elderly" 9 : 189-194, 2005

      5 Viollet, B., "Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders" 33 : 395-402, 2007

      6 Zhan, T., "Synthesis of azole nucleoside analogues of D-pinitol as potential antitumor agents" 342 : 865-869, 2007

      7 Sia,C., "Spotlight on ethnomedicine: Usability of Sutherlandia flutescens in the treatment of diabetes" 1 : 145-149, 2004

      8 Kipfer-Coudreau, S. D., "Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects" 47 : 1278-1284, 2004

      9 Larner, J., "Rat liver insulin mediator which stimulates pyruvate dehydrogenase phosphatase contains galac- tosamine and D-chiroinositol" 151 : 1416-1426, 1988

      10 Gu, F., "Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress" 279 : 49689-49693, 2004

      11 Narayanan, C. R., "Pinitol– a new anti-diabetic compound from the leaves of Bougainvillea spectabilis" 56 : 139-141, 1987

      12 Sethi, G., "Pinitol targets nuclear factor-kB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis" 7 : 1604-1614, 2008

      13 Jae Cherl Kim, "Pinitol from Soybeans Reduces Postprandial Blood Glucose in Patients with Type 2 Diabetes Mellitus" 한국식품영양과학회 9 (9): 182-186, 2006

      14 Suzuki, S., "Molecular mechanism of insulin resistance in spontaneous diabetic GK (Goto- Kakizaki) rats in New Directions in Research and Clinical Works for Obesity and Diabetes Mellitus" Elsevier Science Publishers 197-203, 1991

      15 Kennington, A. S., "Low urinary chiro-inositol excretion in non-insulin-dependent diabetes mellitus" 323 : 373-378, 1990

      16 Bates, S. H., "Insulin-like effect of pinitol" 130 : 1944-1948, 2000

      17 Farese, R. V., "Insulin-induced activation of glycerol-3-phosphate acyl- transferase by a chiro-inositol containing insulin mediator is defective in adipocytes of insulin-resistant, type II diabetic, Goto-Kakizaki rats" 91 : 11040-11044, 1994

      18 Jarret, L., "Insulin mediator from rat skeletal muscle have differential effect on insulin-sensitive pathway of infact adipocytes" 227 : 533-535, 1985

      19 Fontales, M. C., "Infusion of pH 2.0 D-chiro-inositol glycan insulin putative mediator normalizes plasma glucose in streptozotocin diabetic rats at a dose equivalent to insulin without inducing hypoglycaemia" 39 : 731-734, 1996

      20 Pak, Y., "In vivo conversion of [3H]myo- inositol to [3H]chiro-inositol in rat tissue" 267 : 16904-16910, 1992

      21 Pak, Y., "In vivo chiro- inositol metabolism in rat: A defect in chiro-inositol synthesis from myo-inositol and an increased incorporation of chiro- [3H]inositol into phospholipids in the Goto-Kakizaki (G. K.) rat" 8 : 301-309, 1998

      22 Ortmeyer, H. K., "Effects of D-chiroinositol added to a meal on plasma glucose and insulin in hyperinsulinemic rhesus monkeys" 3 : S605-S608, 1995

      23 Iuorno, M. J., "Effects of D-chiro-inositol in lean women with the polycystic ovary syndrome" 8 : 417-423, 2002

      24 Davis, A., "Effect of pinitol treatment on insulin action in subjects with insulin resistance" 23 : 1000-1005, 2000

      25 Lee, D. T., "Effect of pinitol supplementation and strength training on anaerobic performance and status of energy substrates in healthy young men" 8 : 189-195, 2005

      26 Kim, J. I., "Effect of pinitol isolated from soybeans on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus: a randomized controlled study" 59 : 456-458, 2005

      27 Chun,S.H., "Devlopment and therapeutic perspective of type 2 Diabetes Mellitus" 9 : 204-219, 2004

      28 Buford, T. W., "Creatine supplementation and exercise" 4 : 6-6, 2007

      29 Huang, L. C., "Chiroinositol deficiency and insulin resistance. III. Acute glycogenic and hypoglycemic effects of two inositol phosphoglycan insulin mediators in normal and streptozotocin-diabetic rats in vivo" 132 : 652-657, 1993

      30 Ortmeyer, H. K., "Chiroinositol deficiency and insulin resistance. II. Acute effect of chiroinositol administration in streptozotocin-diabetic rats, normal rats given a glucose load, and spontaneously insulin-resistance in spontaneously diabetic rhesus monkeys" 132 : 646-651, 1993

      31 Ortmeyer, H. K., "Chiroinositol deficiency and insulin resistance. I. Urinary excretion rate of chiroinositol is directly associated insulin resistance in spontaneously diabetic rhesus monkeys" 132 : 640-645, 1993

      32 Asplin, I., "Chiro-inositol deficiency and insulin resistance: A comparison of the chiro- inositol and myo-inositon containing insulin mediators isolated from urine, hemo- dialysate, and muscle of control and type II diabetic subjects" 90 : 5924-5928, 1993

      33 Fonteles, M. C., "Antihyperglycemic effects of 3-O-methyl-D-chiro-inositol and D-chiro-inositol associated with managanese in streptozotocin diabetic rats" 32 : 129-132, 2000

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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.37 0.37 0.42
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.43 0.43 0.774 0.09
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