Sprague-Dawley 랫드를 이용한 신이 추출물의 4주 반복 용량 결정 독성시험 = 4-week dose range finding toxicity test of Magnoliae Flos extract in Sprague-Dawley rats

다국어 초록 (Multilingual Abstract)

Medicinal herb demonstrated in many pharmacological effects and recognized to be safe has been used for a long time.
However, side effects including safety of medicinal herb have not been identified yet. The aim of the study was to estimate safety evaluation of Magnoliae Flos used for the treatment of pain, rhinitis, and pneumonia in Korea, China and Japan through fourweek dose range finding toxicity test in male and female Sprague- Dawley rats. Magnoliae Flos was orally administered to male and female SD rats once a day for 28 days at 1,500 and 3,000 mg/kg.
The safety evaluation was determined to examine clinical signs, mortality, body weight, food intake, hematology, serum biochemistry and relative organ weights and there were no significant changes related toxicity. Consequently, these findings indicates that Magnoliae Flos did not show any side effects including toxicity in dose range finding toxicity test and the no observed adverse effect level for Magnoliae Flos was estimated as more than 3,000 mg/kg.