철과 철 경화제가 마우스의 Vibrio vulnificus 패혈증에 미치는 영향 = Effect of Iron and Its Chelators on Vibrio vulnificus Septicemia Experimentally Induced in Mice철과 철 경화제가 마우스의 Vibrio vulnificus 패혈증에 미치는 영향

다국어 초록 (Multilingual Abstract)

Infection with V. vulnificus resulting in septicemia accompanied with skin gangrene and high mortality of 50% or more freqently occurs in people with liver disenses. And it has also been demonstrated that serum iron, essential to the growth of microorganisms, has been elevated in liver damaged animals. In spite of many efforts to reveal the pathogenesis of this fatal disease, there is no clear conclusion so far. Significant increase
or decrease in LD of V. vulnificus (CDC C7184) was observed when mice were treated with ferric arnmonium citrate (FAC) and a specific iron chelator, desferal(Df), originated from Streptomyces pilosus and a broad spectrurn cation chelator, calciurn disodium ethylenediaminetetraacetate (CaEDTA) widly used in heavy metal poisoning treated alone or in combination. The results were obtained as follows. FAC and Df lowered LD to approximately 1.96x 10 colony forming unit (CFU) and 9.77x10 CFU respectively from 4.46 x 10 CFU, LDso of the control group. However, CaEDTA elevated the I D to 4.97
X 10 CFU. The LD of the group administered FAC and Df simultaneously was about 9.28x10' CFU. Whereas, the LD of the group administered FAC and CaEDTA simultaneously was approximately 7.88 x J.O similar to that of the control group. This
study demonstrates that there is a close association of the iron with V. vulnificus
septicemia and Df lowers LD of the rnice. CaED7A, however, elevated the LD. The author hereby proposes carefully iron chelators such as CaEDTA as an agent for a new adjuvant therapy of the V. vulnificus septicernia.