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      KCI등재 SCIE SCOPUS

      Radiographic Characteristics of Caudal Segment in Multilevel Anterior Cervical Discectomy and Fusion: T he Bony Buttress Formation

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      https://www.riss.kr/link?id=A109470070

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      Objective: Anterior cervical discectomy and fusion (ACDF) with anterior plating is a commonly performed procedure for cervical disc diseases. While the clinical outcomes of most reported multilevel ACDF cases are excellent, symptomatic pseudarthrosis remains a challenge, often requiring revision surgeries. This study aims to present the radiological characteristics of multilevel ACDF constructs, which can be considered during intraoperative management to prevent pseudarthrosis.
      Methods: This retrospective cohort study included patients who underwent multilevel (3 or 4 levels) ACDF with anterior plating between June 2010 and August 2022. Patients were regularly followed at 4 months, 12 months, and then annually postoperation. Fusion rates and characteristic radiological patterns, such as the formation of bony buttresses underneath the anterior plate, were graded and evaluated.
      Results: A total of 163 patients were included in the study. Overall fusion rates were 26.38%, 64.34%, and 81.58% at 4-month, 1-year, and the final follow-up, respectively. Nonunions at 4-month follow-up with tightly engaged anterior plate with bony buttress formation were more likely to fuse in the later period (Buttress grade 0 vs. 1; p = 0.01, odds ratio [OR], 5.70, Buttress grade 1 vs. > 2; p < 0.01, OR, 12.00).
      Conclusion: This study emphasizes the significance of pseudarthrosis following multilevel ACDF. Pseudarthrosis predominantly occurs in the caudal-most segment of the construct, particularly when it terminates at C7. Constructs that are not tightly engaged and lack bony buttress formation in the caudal part of multilevel ACDF are more likely to develop pseudarthrosis.
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      Objective: Anterior cervical discectomy and fusion (ACDF) with anterior plating is a commonly performed procedure for cervical disc diseases. While the clinical outcomes of most reported multilevel ACDF cases are excellent, symptomatic pseudarthrosis ...

      Objective: Anterior cervical discectomy and fusion (ACDF) with anterior plating is a commonly performed procedure for cervical disc diseases. While the clinical outcomes of most reported multilevel ACDF cases are excellent, symptomatic pseudarthrosis remains a challenge, often requiring revision surgeries. This study aims to present the radiological characteristics of multilevel ACDF constructs, which can be considered during intraoperative management to prevent pseudarthrosis.
      Methods: This retrospective cohort study included patients who underwent multilevel (3 or 4 levels) ACDF with anterior plating between June 2010 and August 2022. Patients were regularly followed at 4 months, 12 months, and then annually postoperation. Fusion rates and characteristic radiological patterns, such as the formation of bony buttresses underneath the anterior plate, were graded and evaluated.
      Results: A total of 163 patients were included in the study. Overall fusion rates were 26.38%, 64.34%, and 81.58% at 4-month, 1-year, and the final follow-up, respectively. Nonunions at 4-month follow-up with tightly engaged anterior plate with bony buttress formation were more likely to fuse in the later period (Buttress grade 0 vs. 1; p = 0.01, odds ratio [OR], 5.70, Buttress grade 1 vs. > 2; p < 0.01, OR, 12.00).
      Conclusion: This study emphasizes the significance of pseudarthrosis following multilevel ACDF. Pseudarthrosis predominantly occurs in the caudal-most segment of the construct, particularly when it terminates at C7. Constructs that are not tightly engaged and lack bony buttress formation in the caudal part of multilevel ACDF are more likely to develop pseudarthrosis.

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      참고문헌 (Reference)

      1 Lambrechts MJ, "What is the role of dynamic cervical spine radiographs in predicting pseudarthrosis revision following anterior cervical discectomy and fusion" 22 : 1610-1621, 2022

      2 Lee DH, "What is the fate of pseudarthrosis detected 1 year after anterior cervical discectomy and fusion?" 43 : E23-E28, 2018

      3 Cho DY, "Treatment of multilevel cervical fusion with cages" 62 : 378-386, 2004

      4 Emery SE, "Three-level anterior cervical discectomy and fusion: radiographic and clinical results" 22 : 2622-2625, 1997

      5 Papadopoulos EC, "Three-level anterior cervical discectomy and fusion with plate fixation:radiographic and clinical results" 31 : 897-902, 2006

      6 Song KJ, "Three-and four-level anterior cervical discectomy and fusion with a PEEK cage and plate construct" 21 : 2492-2497, 2012

      7 Bolesta MJ, "Three- and fourlevel anterior cervical discectomy and fusion with plate fixation:a prospective study" 25 : 2040-2046, 2000

      8 Smith GW, "The treatment of certain cervicalspine disorders by anterior removal of the intervertebral disc and interbody fusion" 40-A : 607-624, 1958

      9 Akiro H. Duey ; Christopher Gonzalez ; Eric A. Geng ; Pierce J. Ferriter Jr ; Ashley M. Rosenberg ; Ula N. Isleem ; Bashar Zaidat ; Paul M. Al-Attar ; Jonathan S. Markowitz ; Jun S. Kim ; Samuel K. Cho, "The effect of subsidence on segmental and global lordosis at long-term follow-up after anterior cervical discectomy and fusion" 19 : 927-934, 2022

      10 Emery SE, "Robinson anterior cervical fusion comparison of the standard and modified techniques" 19 : 660-663, 1994

      1 Lambrechts MJ, "What is the role of dynamic cervical spine radiographs in predicting pseudarthrosis revision following anterior cervical discectomy and fusion" 22 : 1610-1621, 2022

      2 Lee DH, "What is the fate of pseudarthrosis detected 1 year after anterior cervical discectomy and fusion?" 43 : E23-E28, 2018

      3 Cho DY, "Treatment of multilevel cervical fusion with cages" 62 : 378-386, 2004

      4 Emery SE, "Three-level anterior cervical discectomy and fusion: radiographic and clinical results" 22 : 2622-2625, 1997

      5 Papadopoulos EC, "Three-level anterior cervical discectomy and fusion with plate fixation:radiographic and clinical results" 31 : 897-902, 2006

      6 Song KJ, "Three-and four-level anterior cervical discectomy and fusion with a PEEK cage and plate construct" 21 : 2492-2497, 2012

      7 Bolesta MJ, "Three- and fourlevel anterior cervical discectomy and fusion with plate fixation:a prospective study" 25 : 2040-2046, 2000

      8 Smith GW, "The treatment of certain cervicalspine disorders by anterior removal of the intervertebral disc and interbody fusion" 40-A : 607-624, 1958

      9 Akiro H. Duey ; Christopher Gonzalez ; Eric A. Geng ; Pierce J. Ferriter Jr ; Ashley M. Rosenberg ; Ula N. Isleem ; Bashar Zaidat ; Paul M. Al-Attar ; Jonathan S. Markowitz ; Jun S. Kim ; Samuel K. Cho, "The effect of subsidence on segmental and global lordosis at long-term follow-up after anterior cervical discectomy and fusion" 19 : 927-934, 2022

      10 Emery SE, "Robinson anterior cervical fusion comparison of the standard and modified techniques" 19 : 660-663, 1994

      11 Mullins J, "Retrospective singlesurgeon study of 1123 consecutive cases of anterior cervical discectomy and fusion : a comparison of clinical outcome parameters, complication rates, and costs between outpatient and inpatient surgery groups, with a literature review" 28 : 630-641, 2018

      12 Alhashash Mohamed ; Zentralklinik Bad Berka, Bad Berka, Germany ; Boehm Heinrich ; Shousha Mootaz, "Results of fourlevel anterior cervical discectomy and fusion using standalone interbody titanium cages" 16 : 82-91, 2022

      13 Oshina M, "Radiological fusion criteria of postoperative anterior cervical discectomy and fusion : a systematic review" 8 : 739-750, 2018

      14 Hilibrand AS, "Radiculopathy and myelopathy at segments adjacent to the site of a previous anterior cervical arthrodesis" 81 : 519-528, 1999

      15 Pennington Z, "Quality of life and cost implications of pseudarthrosis after anterior cervical discectomy and fusion and its subsequent revision surgery" 133 : e592-e599, 2020

      16 김수한 ; 이정길 ; 장재원 ; 박현웅 ; 허혁, "Polyetheretherketone cage with demineralized bone matrix can replace iliac crest autografts for anterior cervical discectomy and fusion in subaxial cervical spine injuries" 60 : 211-219, 2017

      17 Song KJ, "Plate augmentation in anterior cervical discectomy and fusion with cage for degenerative cervical spinal disorders" 19 : 1677-1683, 2010

      18 Cusick JF, "Pathophysiology and treatment of cervical spondylotic myelopathy" 37 : 661-681, 1991

      19 De la Garza-Ramos R, "Long-term clinical outcomes following 3-and 4-level anterior cervical discectomy and fusion" 24 : 885-891, 2016

      20 Wang JC, "Increased fusion rates with cervical plating for three-level anterior cervical discectomy and fusion" 26 : 643-647, 2001

      21 Wewel JT, "Fusion rate following three-and four-level ACDF using allograft and segmental instrumentation : a radiographic study" 62 : 142-146, 2019

      22 Chang SW, "Four-level anterior cervical discectomy and fusion with plate fixation : radiographic and clinical results" 66 : 639-646, 2010

      23 Conor P. Lynch ; Elliot D.K. Cha ; Madhav R. Patel ; Caroline N. Jadczak ; Shruthi Mohan ; Cara E. Geoghegan ; Kern Singh, "Effects of anterior plating on achieving clinically meaningful improvement following single-level anterior cervical discectomy and fusion" 19 : 315-322, 2022

      24 Lee NJ, "Does screw length for primary two-level ACDF influence pseudarthrosis risk" 20 : 1752-1760, 2020

      25 Zadegan SA, "Demineralized bone matrix in anterior cervical discectomy and fusion : a systematic review" 26 : 958-974, 2017

      26 Kim HC, "Comparison of the effectiveness and safety of bioactive glass ceramic to allograft bone for anterior cervical discectomy and fusion with anterior plate fixation" 43 : 1423-1430, 2020

      27 Liu Y, "Comparison of 3 reconstructive techniques in the surgical management of multilevel cervical spondylotic myelopathy" 37 : E1450-E1458, 2012

      28 Kreitz TM, "Clinical outcomes after four-level anterior cervical discectomy and fusion" 8 : 776-783, 2018

      29 이정환 ; 이연주 ; 장민철 ; 이준호, "Clinical effectiveness of artificial disc replacement in comparison with anterior cervical discectomy and fusion in the patients with cervical myelopathy : systematic review and meta-analysis" 20 : 1047-1060, 2023

      30 Nichols NM, "Characterizing the fusion order and level-specific rates of arthrodesis in 3-level anterior cervical discectomy and fusion : a radiographic study" 81 : 328-333, 2020

      31 Anderst WJ, "Cervical motion segment contributions to head motion during flexion\extension, lateral bending, and axial rotation" 15 : 2538-2543, 2015

      32 Chen JH, "Boning up on Wolff’s law : mechanical regulation of the cells that make and maintain bone" 43 : 108-118, 2010

      33 Lee A. Tan ; Narayan Yoganandan ; Hoon Choi ; Yuvaraj Purushothaman ; Davidson Jebaseelan ; Aju Bosco, "Biomechanical analysis of 3-level anterior cervical discectomy and fusion under physiologic loads using a finite element model" 19 : 385-392, 2022

      34 Malloy KM, "Autograft versus allograft in degenerative cervical disease" (394) : 27-38, 2002

      35 Phillips FM, "Anterior cervical pseudarthrosis. Natural history and treatment" 22 : 1585-1589, 1997

      36 Jiang SD, "Anterior cervical discectomy and fusion versus anterior cervical corpectomy and fusion for multilevel cervical spondylosis : a systematic review" 132 : 155-161, 2012

      37 Fountas KN, "Anterior cervical discectomy and fusion associated complications" 32 : 2310-2317, 2007

      38 Emery SE, "Anterior cervical decompression and arthrodesis for the treatment of cervical spondylotic myelopathy. Two to seventeen-year follow-up" 80 : 941-951, 1998

      39 Nirala AP, "A retrospective study of multiple interbody grafting and long segment strut grafting following multilevel anterior cervical decompression" 18 : 227-232, 2004

      40 Li Z, "A comparison of multilevel anterior cervical discectomy and corpectomy in patients with 4-level cervical spondylotic myelopathy : a minimum 2-year follow-up study : multilevel anterior cervical discectomy" 30 : E540-E546, 2017

      41 Koller H, "4-and 5-level anterior fusions of the cervical spine : review of literature and clinical results" 16 : 2055-2071, 2007

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