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      해조류 다당류와 Chitosan, Chitin의 항바이러스 효과 = Antiviral Activity of Chitosan, Chitin and Polysaccharides Derived From Seaweed

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      https://www.riss.kr/link?id=A106916179

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      다국어 초록 (Multilingual Abstract)

      The corona virus is terrifying and fearing people all over the world. About 8 million people have been identified worldwide and about 400,000 have died, threatening human health since the Spanish flu in the early 20th century. To overcome COVID-19, no...

      The corona virus is terrifying and fearing people all over the world. About 8 million people have been identified worldwide and about 400,000 have died, threatening human health since the Spanish flu in the early 20th century. To overcome COVID-19, no specific antiviral treatment or vaccine has been developed that can be used to control or suppress infection. More than 300 drugs are being developed for prophylactic and therapeutic purposes because the development of therapeutic agents is required before vaccine development, and many drugs are in clinical trials. In addition, vaccine development is actively underway to complete the end of COVID-19. In addition, major countries around the world, including Korea, are participating in vaccine development. On the other hand, the study of natural antiviral substances to improve safety by following the treatment of COVID-19 before the vaccine is developed is also of interest. In natural products with antiviral activity, propolis, Manuka honey, boswellia gem, myrrh and xylitol, and many essential oils and polyphenols are attracting attention. Along with this, marine polysaccharides such as carrageenan, alginic acid, fucan and chitosan are also of great interest. Chitosan, which is the central theme of this society, has been shown to be a hope for the complete overcoming of COVID-19 by exhibiting high binding and high antiviral effects with viruses due to its molecular properties and its characteristic transformation. Corona virus vaccines have been developed in the future and we hope that they will be used as a wide range of antiviral substances until we return to a safe routine.

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      참고문헌 (Reference)

      1 박수은, "코로나바이러스감염증-19의 바이러스(SARS-CoV-2) 특징, 전파 및 임상 양상" 대한소아감염학회 27 (27): 1-10, 2020

      2 "코로나바이러스감염증-19(COVID-19) 질병관리본부 환자 현황"

      3 Mercer, J., "Virus entry by endocytosis" 79 : 803-833, 2010

      4 Harden, E. A., "Virucidal activity of polysaccharide extracts from four algal species against herpes simplex virus" 83 : 282-289, 2009

      5 Copeland, R., "Using a 3-O-sulfated heparin octasaccharide to inhibit the entry of herpes simplex virus type 1" 47 : 5774-5783, 2008

      6 Kim, S. K., "Therapeutic prospectives of chitin, chitosan and their derivatives" 11 : 1-10, 2006

      7 Carter, D. A., "Therapeutic Manuka Honey: No Longer So Alternative" 569 : 1-11, 2016

      8 Geng, M. Y., "The potential molecular targets of marine sulfated polymannuroguluronate interfering with HIV-1 entry Interaction between SPMG and HIV-1 gp120 and CD4 molecule" 59 : 127-135, 2003

      9 Wang, W., "The application of polymannuronic acid propyl sulfate in the preparation of drugs against influenza A (H1N1) virus"

      10 Biancatelli, R. M. L. C., "The antiviral properties of vitamin C" 18 : 99-101, 2020

      1 박수은, "코로나바이러스감염증-19의 바이러스(SARS-CoV-2) 특징, 전파 및 임상 양상" 대한소아감염학회 27 (27): 1-10, 2020

      2 "코로나바이러스감염증-19(COVID-19) 질병관리본부 환자 현황"

      3 Mercer, J., "Virus entry by endocytosis" 79 : 803-833, 2010

      4 Harden, E. A., "Virucidal activity of polysaccharide extracts from four algal species against herpes simplex virus" 83 : 282-289, 2009

      5 Copeland, R., "Using a 3-O-sulfated heparin octasaccharide to inhibit the entry of herpes simplex virus type 1" 47 : 5774-5783, 2008

      6 Kim, S. K., "Therapeutic prospectives of chitin, chitosan and their derivatives" 11 : 1-10, 2006

      7 Carter, D. A., "Therapeutic Manuka Honey: No Longer So Alternative" 569 : 1-11, 2016

      8 Geng, M. Y., "The potential molecular targets of marine sulfated polymannuroguluronate interfering with HIV-1 entry Interaction between SPMG and HIV-1 gp120 and CD4 molecule" 59 : 127-135, 2003

      9 Wang, W., "The application of polymannuronic acid propyl sulfate in the preparation of drugs against influenza A (H1N1) virus"

      10 Biancatelli, R. M. L. C., "The antiviral properties of vitamin C" 18 : 99-101, 2020

      11 Talarico, L. B., "The antiviral activity of sulfated polysaccharides against dengue virus is dependent on virus serotype and host cell" 66 : 103-110, 2005

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      24 Matsuhiro, B., "Structural analysis and antiviral activity of a sulfated galactan from the red seaweed Schizymenia binderi (Gigartinales, Rhodophyta)" 340 : 2392-2402, 2005

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      35 Muto, S., "Polysaccharides from marine algae and antiviral drugs containing the same as active ingredients"

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      40 Liu, H. Y., "Multiple and multivalent interactions of novel anti-AIDS drug candidates, sulfated polymannuronate(SPMG)-derived oligosaccharides, with gp120 and their anti-HIV activities" 15 : 501-510, 2005

      41 Mazumder, S., "Isolation, chemical investigation and antiviral activity of polysaccharides from Gracilaria corticata(Gracilariaceae, Rhodophyta)" 31 : 87-95, 2002

      42 Akamatsu, E., "Isolation of an anti-influenza virus substance, MC26 from a marine brown alga, Sargassum piluliferum and its antiviral activity against influenza virus" 29-34, 2003

      43 Leibbrandt, A., "Iota-carrageenan is a potent inhibitor of influenza A virus infection" 5 : e14320-, 2010

      44 Grassauer, A., "Iota-Carrageenan is a potent inhibitor of rhinovirus infection" 5 : 107-, 2008

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      46 Talarico, L. B., "Interference in dengue virus adsorption and uncoating by carrageenans" 363 : 473-485, 2007

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      49 Queiroz, K. C. S., "Inhibition of reverse transcriptase activity of HIV by polysaccharides of brown algae" 62 : 303-307, 2008

      50 Pospieszny, H., "Induction of antiviral resistance in plants by chitosan" 79 : 63-68, 1991

      51 Zhou, G., "In vivo antitumor and immunomodulation activities of different molecular weight lambda-carrageenans from Chondrus ocellatus" 50 : 47-53, 2004

      52 Wang, W., "In vitro inhibitory effect of carrageenan oligosaccharide on influenza A H1N1 virus" 92 : 237-246, 2011

      53 Kim, J. K., "In vitro and in vivo immunomodulatory activity of sulfated polysaccharides from Enteromorpha prolifera" 49 : 1051-1058, 2011

      54 Yuan, H. M., "Immunomodulation and antitumor activity of κ-carrageenan oligosaccharides" 243 : 228-234, 2006

      55 Li, S. Chen, C., "Identification of natural compounds with antiviral activities against SARS-associated coronavirus" 67 : 18-23, 2005

      56 Carlucci, M. J., "Herpes simplex virus type 1variants arising after selection with an antiviral carageenan: Lack of correlation between drug susceptibility and syn phenotype" 68 : 92-98, 2002

      57 Nelson, R. M., "Heparin oligosaccharidesbind L-and P-selectin and inhibit acute inflammation" 82 : 3253-3258, 1993

      58 Delattre, C., "Galactans: an overview of their most important sourcing and applications as natural polysaccharides" 54 : 1075-1092, 2011

      59 Rodr´ıguez, M. C., "Galactans from cystocarpic plants of the red seaweed Callophyllis variegata (Kallymeniaceae, Gigartinales)" 340 : 2742-2751, 2005

      60 Douglas, M. S., "Endothelial production of MCP-1: Modulation by heparin and consequences for mononuclear cell activation" 92 : 512-518, 1997

      61 Dou, J. L., "Effects of chitooligosaccharides on rabbit neutrophils in vitro" 69 : 209-213, 2007

      62 Davis, R., "Effectiveness of chitosan on the inactivation of enteric viral surrogates" 32 : 57-62, 2012

      63 Kulikov, S. N., "Effect of the molecular weight of chitosan on its antiviral activity in plants" 42 : 224-228, 2006

      64 Su, X. W., "Effect of chitosan on the infectivity of murine norovirus, feline calicivirus, and bacteriophage MS2" 72 : 2623-2628, 2009

      65 Pospieszny, H., "Effect of chitosan on the hypersensitive reaction of bean to alfalfa mosaic virus" 62 : 29-31, 1989

      66 Talarico, L. B., "Differential inhibition of dengue virus infection in mammalian and mosquito cells by iota-carrageenan" 92 : 1332-1342, 2011

      67 Madeleine, L. M., "Dextran sulfate inhibits the fusion of influenza virus with model membranes, and suppresses influenza virus replication in vivo" 14 : 39-50, 1990

      68 Lahaye, M., "Developments on gelling algal galactans, their structure and physico-chemistry" 13 : 173-184, 2001

      69 Estevez, J. M., "DL-Galactan hybrids and agarans from gametophytes of the red seaweed Gymnogongrus torulosus" 331 : 27-41, 2001

      70 Peng, X. M., "Current Developments of Coumarin Compounds in Medicinal Chemistry" 19 : 3884-3930, 2013

      71 Wrapp, D., "Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation" 13 (13): 1260-1263, 2020

      72 Mishra, S., "Coumarin: An emerging antiviral agent Heliyon" 6 : e03217-, 2020

      73 Jeon, Y. J., "Continuous production of chitooligosaccharides using a dual reactor system" 35 : 623-632, 2000

      74 Davydova, V. N., "Chitosan antiviral activity: Dependence on structure and depolymerization method" 47 : 113-118, 2011

      75 Jiao, G., "Chemical structures and bioactivities of sulphated polysaccharides from marine algae" 9 : 196-223, 2011

      76 Buck, C. B., "Carrageenan is a potent inhibitor of papillomavirus infection" 2 : e69-, 2006

      77 전환주, "COVID-19 대응을 위한 국내외 치료제 및 백산개발 현황과 과제" 2-32, 2020

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      79 Rashan, L., "Boswellia Gum Resin and Essential Oils: Potential Health Benefits - An Evidence Based Review" 9 : 53-71, 2019

      80 Ji, J., "Bio-function summary of marine oligosaccharides" 3 : 74-86, 2011

      81 Okazaki, K., "BHV-1 adsorption is mediated by the interaction of glycoprotein gIII with heparinlike moiety on the cell surface" 181 : 666-670, 1991

      82 Girond, S., "Antiviral activity of carrageenan on hepatitis A virus replication in cell culture" 142 : 261-270, 1991

      83 Ahmadi, A., "Antiviral Potential of Algae Polysaccharides Isolated from Marine Sources: A Review" 1-10, 2015

      84 Ahmadi, A., "Antiviral Potential of Algae Polysaccharides Isolated from Marine Sources: A Review" 2015 : 825203-, 2015

      85 Ho, H. Y., "Antiviral Effect of Epigallocatechin Gallate on Enterovirus 71" 57 : 6140-6147, 2009

      86 Schnitzler, P., "Antiviral Activity and Mode of Action of Propolis Extracts and Selected Compounds" 24 : 20-28, 2010

      87 Min S. K., "Antiviral Activity Screening of Aqueous Extracts from Indigenous Plants" 19 : 9-19, 2009

      88 Yu, L., "Antitumor effect of butanoylated heparin with low anticoagulantactivity on lung cancer growth in mice and rats" 10 : 229-241, 2010

      89 Carlucci, M. J., "Antiherpetic and anticoagulant properties of carrageenans from the red seaweed Gigartina skottsbergii and their cyclized derivatives: Correlation between structure and biological activity" 20 : 97-105, 1997

      90 Carlucci, M. J., "Antiherpetic activity and mode of action of natural carrageenans of diverse structural types" 43 : 93-102, 1999

      91 Carlucci, M. J, "Antiherpetic activity and mode of action of natural carrageenans of diverse structural types" 43 : 93-102, 1999

      92 Brochot, A., "Antibacterial, antifungal, and antiviral effects of three essential oil blends" 6 : 459-465, 2017

      93 Artan, M., "Anti-HIV-1 activity of low molecular weight sulfated chitooligosaccharides" 345 : 656-662, 2010

      94 Karagozlu, M. Z., "Anti-HIV activities of novel synthetic peptide conjugated chitosan oligomers" 66 : 260-266, 2014

      95 Talarico, L. B., "An algal-derived DL-galactan hybrid is an efficient preventing agent for in vitro dengue virus infection" 73 : 1464-1468, 2007

      96 Xu, M. L., "Ameliorating Effect of Dietary Xylitol on Human Respiratory Syncytial Virus(hRSV)Infection" 39 : 540-546, 2016

      97 Witvrouw, M., "Activity of a sulfated polysaccharide extracted fromthe red seaweed Aghardhiella tenera against human immunodeficiency virus and other enveloped viruses" 5 : 297-303, 1994

      98 Kari, B., "A human cytomegalovirus glycoproteincomplex designated gC-II is a major heparin-binding component of the envelope" 66 : 1761-1764, 1992

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      2020-01-01 평가 등재학술지 선정 (재인증) KCI등재
      2019-12-01 평가 등재후보로 하락 (계속평가) KCI등재후보
      2016-01-01 평가 등재학술지 선정 (계속평가) KCI등재
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      2016 0.28 0.28 0.26
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.23 0.23 0.481 0.13
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