C57BL/6 마우스 모델에서 NDM 발모제의 모발성장 촉진 효과 = Effect of NDM Hair Tonic on Hair Growth Promotion in An Alopecia Model of C57BL/6 Mice

다국어 초록 (Multilingual Abstract)

NDM hair tonic is composed of several plant extracts which are known to be used in oriental medicine. This study was carried out to investigate effect of NDM hair tonic on hair growth in an alopecia model of C57BL/6 mice. Hair of six-weeks old mice were removed by topical treatment of Neclean<SUP>Ⓡ</SUP>, The next day, animals were randomized and separated in groups of 6 mice. There were four experimental groups including saline (negative control), 50% ethanol (vehicle control), 3% minoxidil (MXD), and NDM tonic. The test compounds were topically treated with 0.15 ㎖ per mouse per day for 2 weeks. The hair regrowth was determined photographically and histologically and the quantity of endocrine factors, IGF-1 and TGF-β, in the skin of mice using PCR was measured. No clinical signs were found in all animals. The topical treatment of NDM tonic or MXD for 2 weeks to dorsal skin accelerated hair regrowth faster than the controls. The NDM tonic or MXD treatment also promoted hair follicle elongation compared to the controls. The NDM tonic or MXD treatment significantly increased the expression of IGF-1 in the skin of C57BL/6 mice compared to the control (p＜0.05). These results suggest that NDM-tonic has hair growth promoting activities and it can be useful for treatment for baldness or alopecia.

목차 (Table of Contents)

• 서론
• 재료 및 방법
• 결과
• 고찰
• 감사의 글
• 참고문헌