뚜레장애와 인간조직적합성항원(HLA) = Tourette's Disorder and Histocompatibility Antigen

다국어 초록 (Multilingual Abstract)

The authors studied HLA of 73 Tourette's dosorder (TD) patients. They all met DSM-Ⅲ-R criteria of Tourette's disorder. The total patients were divided into two groups. one with positive family history and the other with negative family history. The former included those patients with family histories of the one or more tic disorders and obsessive compulsive disorders (OCD) (all were 31), and the latter included patients without any histories of tic disorders, OCD, attention deficit hyperactivity disorder and obsessive compulsive charcter taits(all were 29). The normal control group composed of 291 healthy living unrelated kidney donors of both sex. HLA typings were done modified Tersaki(Amos) method.
The frequenciess of HLA were compared with chi-square test and p value was corrected by multiplying the number of the tested antigens to avoid the Type 1 error.
HLA-All(p〈0.05), HLA-A26(10)(p〈0.005) were increased in frequency in total Tourette's disorder patient group when compared to normal controls. HLA-A24(p〈0.01), HLA-B13 (p〈0.05) were decreased in total Tourette's patients when compared to the normal control group. HLA-B16(p〈0.05) and HLA-DR4(p〈0.000) were found to be increased in negative family history group and HLA-Cw(p〈0,05) were decreased when each of them were compared to normal control group. But all the findings were insignificant when p value was corrected.