The effects of ethanol (ET) on the teratogenicity of the fat soluble drug, Vita. min A (VA) were examined in SPF Wistar rats. VA and ET were orally administered with sonde. The drugs were administered for 3 days of day 9-11 of gestation. Four groups w...
The effects of ethanol (ET) on the teratogenicity of the fat soluble drug, Vita. min A (VA) were examined in SPF Wistar rats. VA and ET were orally administered with sonde. The drugs were administered for 3 days of day 9-11 of gestation. Four groups were made; G-I control (sesame oil + saline), G-II VA $40{\times}10^{4}$ (I.Ulkg/day), G-III ET 2 (g/kg/day), G-IV $40{\times}10^{4}$ + ET 2. Congenital malformations were found G-II, G-III and G-IV. All fetuses in G-IV combination had malforamtions. Main malformation in G-IV combi. nation were microstomia, disposition of ear, open eyelids brachygnathia and cleft plate. Accordingly it might be demonstrated that the teratogenicity of hypervitaminosis A was pontentiated by concurrent ethanol in rats.