위점막 Ca++ 이 백서의 손상된 위점막 재생에 미치는 영향 = Effects of Luminal Ca++ on the Recovery of Damaged Gastric Mucosa in the Rat 위점막 Ca++ 이 백서의 손상된 위점막 재생에 미치는 영향

다국어 초록 (Multilingual Abstract)

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다국어 초록 (Multilingual Abstract)

A study was undertaken to investigate the influence of luminal Ca++ on the integrity of normal mucosa and the recovery process of damaged mucosa in rat stomachs using a perfusion system. The results were as follows: 1) The exposure of the stomach to EDTA at concentrations over 50mM significantly reduced the potential difference (PDimV). 2) Perfusion of the stomach with 5mM Ca++ led to a rapid recovery of the PD, which was reduced by preperfusion with 250mM EDTA. 3) An application of 50~9~o and 100% ethanol caused a rapid reduction of the ID and an addition of 5mM Ca++ significantly enhanced the recovery process of the damaged gastric mucosa. 4) An application of 0.4 M NaC1 and 1 M NaC1 also caused a prompt decrease of the PD and after an addition of 5mM CaC1 the reduced PD was increased to a near initial level. 5) The PD changes were well correlated with the microscopical changes of the resected stomach. In conclusion, luminal Ca+ seems to play an important role in maintaining the integrity of normal gastric mucosa and accelerating the recovery process of damaged gastric mucosa in rats.