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      사람피부세포에서 카렌둘라 꽃 추출물의 항산화 및 산화적 스트레스에 대한 세포보호효과 = Antioxidant and Cellular Protective Effects against Oxidative Stress of Calendula officinalis Flowers Extracts in Human Skin Cells

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      https://www.riss.kr/link?id=A102509134

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      다국어 초록 (Multilingual Abstract)

      In this study, we investigated the total phenolic and flavonoid contents, antioxidant activity and cellular protective effects against oxidative stress on human skin cells in 50% ethanol extract and its fractions of Calendula officinalis (C. officinalis) flowers. We measured the antioxidant effects of 50% ethanol extract and its fractions of C. officinalis flowers on the free radical scavenging activity (FSC<sub>50</sub>), the reactive oxygen species (ROS) scavenging activities (OSC<sub>50</sub>) and the inhibition of intracellular ROS generation in human skin cells. These results showed that the antioxidant effect of the ethyl acetate and aglycone fraction was more than the 50% ethanol extract of C. officinalis flowers. We also investigated the cellular protective activity and the results showed that treatment of the ethyl acetate fraction (0.05 - 3.13 μg/mL) protects human skin cells in a concentration-dependent manner when the skin cell damages were induced by treating them with H<sub>2</sub>O<sub>2</sub>. In addition, the aglycone fraction (1.56 - 3.13 μg/mL) shows cellular protective effects on the UV-induced cell damages in a dose-dependent manner. These results suggest that the fractions of C. officinalis flowers can function as a natural antioxidant agent of cosmetics in human skin cells exposed to oxidative stress by ROS scavenging effects.
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      In this study, we investigated the total phenolic and flavonoid contents, antioxidant activity and cellular protective effects against oxidative stress on human skin cells in 50% ethanol extract and its fractions of Calendula officinalis (C. officinal...

      In this study, we investigated the total phenolic and flavonoid contents, antioxidant activity and cellular protective effects against oxidative stress on human skin cells in 50% ethanol extract and its fractions of Calendula officinalis (C. officinalis) flowers. We measured the antioxidant effects of 50% ethanol extract and its fractions of C. officinalis flowers on the free radical scavenging activity (FSC<sub>50</sub>), the reactive oxygen species (ROS) scavenging activities (OSC<sub>50</sub>) and the inhibition of intracellular ROS generation in human skin cells. These results showed that the antioxidant effect of the ethyl acetate and aglycone fraction was more than the 50% ethanol extract of C. officinalis flowers. We also investigated the cellular protective activity and the results showed that treatment of the ethyl acetate fraction (0.05 - 3.13 μg/mL) protects human skin cells in a concentration-dependent manner when the skin cell damages were induced by treating them with H<sub>2</sub>O<sub>2</sub>. In addition, the aglycone fraction (1.56 - 3.13 μg/mL) shows cellular protective effects on the UV-induced cell damages in a dose-dependent manner. These results suggest that the fractions of C. officinalis flowers can function as a natural antioxidant agent of cosmetics in human skin cells exposed to oxidative stress by ROS scavenging effects.

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      참고문헌 (Reference)

      1 하지훈, "한국 제천 감초(Glycyrrhiza uralensis Fisher)의 추출 조건별 추출물의 항산화 및 항균 활성 평가" 대한화장품학회 41 (41): 361-373, 2015

      2 성준섭, "까마중(Solanum nigrum L.) 전초 추출물의 항산화 활성" 한국유화학회 32 (32): 781-788, 2015

      3 M. Kim, "Youngiasides A and C isolated from Youngia denticulatum inhibit UVB-induced MMP expression and promote type I procollagen production via repression of MAPK/AP-1/NF-kappaB and activation of AMPK/Nrf2 in HaCaT Cells and human dermal fibroblasts" 63 : 5428-5438, 2015

      4 L. Packer, "Ultraviolet radiation(UVA,UVB) and skin antioxidants" 28 : 239-255, 1994

      5 C. A. Rice-Evans, "Structure-antioxidant activity relationships of flavonoids and phenolic acids" 20 : 933-956, 1996

      6 M. Wlaschek, "Solar UV irradiation and dermal photoaging" 63 : 41-51, 2001

      7 Y. Al-Nuaimi, "Skin health in older age" 79 : 256-264, 2014

      8 S. N. Park, "Skin aging and antioxidant" 23 : 75-132, 1997

      9 T. Mosmann, "Rapid colorimetric assay for cellular growth and survival:Application to proliferation and cytotoxicity assays" 65 : 55-63, 1983

      10 Y. M. Fonseca, "Protective effect of Calendula officinalis extract against UVB-induced oxidative stress in skin:Evaluation of reduced glutathione levels and matrix metalloproteinase secretion" 127 : 596-601, 2010

      1 하지훈, "한국 제천 감초(Glycyrrhiza uralensis Fisher)의 추출 조건별 추출물의 항산화 및 항균 활성 평가" 대한화장품학회 41 (41): 361-373, 2015

      2 성준섭, "까마중(Solanum nigrum L.) 전초 추출물의 항산화 활성" 한국유화학회 32 (32): 781-788, 2015

      3 M. Kim, "Youngiasides A and C isolated from Youngia denticulatum inhibit UVB-induced MMP expression and promote type I procollagen production via repression of MAPK/AP-1/NF-kappaB and activation of AMPK/Nrf2 in HaCaT Cells and human dermal fibroblasts" 63 : 5428-5438, 2015

      4 L. Packer, "Ultraviolet radiation(UVA,UVB) and skin antioxidants" 28 : 239-255, 1994

      5 C. A. Rice-Evans, "Structure-antioxidant activity relationships of flavonoids and phenolic acids" 20 : 933-956, 1996

      6 M. Wlaschek, "Solar UV irradiation and dermal photoaging" 63 : 41-51, 2001

      7 Y. Al-Nuaimi, "Skin health in older age" 79 : 256-264, 2014

      8 S. N. Park, "Skin aging and antioxidant" 23 : 75-132, 1997

      9 T. Mosmann, "Rapid colorimetric assay for cellular growth and survival:Application to proliferation and cytotoxicity assays" 65 : 55-63, 1983

      10 Y. M. Fonseca, "Protective effect of Calendula officinalis extract against UVB-induced oxidative stress in skin:Evaluation of reduced glutathione levels and matrix metalloproteinase secretion" 127 : 596-601, 2010

      11 A. Kammeyer, "Oxidation events and skin aging" 21 : 16-29, 2015

      12 박수남, "In vitro skin permeation and cellular protective effects of flavonoids isolated from Suaeda asparagoides extracts" 한국공업화학회 18 (18): 680-683, 2012

      13 M. F. Barroso, "Flavored waters: Influence of ingredients on antioxidant capacity and terpenoid profile by HS-SPME/GC-MS" 59 : 5062-5072, 2011

      14 J. Wohlrab, "Epidermal aging and anti-aging strategies" 67 : 107-111, 2016

      15 P. K. Chandran, "Effect of Calendula officinalis flower extract on acute phase proteins, antioxidant defense mechanism and granuloma formation during thermal burns" 43 : 58-64, 2008

      16 D. Bernhard, "Cigarette smoke - an aging accelerator?" 42 : 160-165, 2007

      17 박수남, "Cellular protective effects of dehydroeffusol isolated from Juncus effusus L. and the mechanisms underlying these effects" 한국공업화학회 20 (20): 3046-3052, 2014

      18 T. A. Re, "Application of the threshold of toxicological concern approach for the safety evaluation of calendula flower (Calendula officinalis) petals and extracts used in cosmetic and personal care products" 47 : 1246-1254, 2009

      19 R. C. Alves, "Antiradical activity, phenolics profile, and hydroxymethylfurfural in espresso coffee: Influence of technological factors" 58 : 12221-12229, 2010

      20 K. Zitterl-Eglseer, "Anti-oedematous activities of the main triterpendiol esters of marigold (Calendula officinalis L.)" 57 : 139-144, 1997

      21 S. W. Shin, "Antagonizing effects and mechanisms of afzelin against UVB-induced cell damage" 8 : e61971-, 2013

      22 J. M. Silvan, "A protective effect of anthocyanins and xanthophylls on UVB-induced damage in retinal pigment epithelial cells" 7 : 1067-1076, 2016

      23 E. Jimenez-Medina, "A new extract of the plant Calendula officinalis produces a dual in vitro effect: Cytotoxic anti-tumor activity and lymphocyte activation" 6 : 119-, 2006

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2013-12-01 평가 SCOPUS 등재 (등재유지) KCI등재
      2011-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2010-02-19 학술지명변경 외국어명 : Journal of the Korean Industrial and Engineering Chemistry -> Applied Chemistry for Engineering KCI등재
      2009-04-28 학술지명변경 외국어명 : Jpurnal of the Korean Industrial and Engineering Chemistry -> Journal of the Korean Industrial and Engineering Chemistry KCI등재
      2009-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2007-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2005-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2002-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      1999-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.32 0.32 0.34
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.33 0.33 0.45 0.05
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