Genetics of Ossification of the Posterior Longitudinal Ligament of the Spine: A Mini Review

다국어 초록 (Multilingual Abstract)

Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common dis-ease in aging populations and sometimes results in serious neurological problems dueto compression of the spinal cord and nerve roots. OPLL is a multi-factorial (polygenic)disease controlled by genetic and environmental factors. Studies searching for the ge-netic component of OPLL, using linkage and association analyses, are in progress andseveral susceptibility genes have been reported. This paper reviews the recent progressin the genetic study of OPLL and comments on its future task.

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