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      LDH 나노입자 기반의 바이오 이미징 소재 = Layered Double Hydroxide Nanoparticles for Bio-Imaging Applications

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      https://www.riss.kr/link?id=A106308752

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      국문 초록 (Abstract)

      Layered double hydroxides (LDHs) 나노입자는 특유의 층상형 결정구조에서 기인된 물리화학적 물성 및 생체친화성을 바탕으로 나노-바이오 분야에서 주목을 받고 있다. 바이오 이미징은 질병의 진단과 치료(테라노스틱스, theranostics=therapy+diagnosis)에 다양하게 활용될 수 있는 핵심적인 분야로 차세대 맞춤의학으로의 새로운 패러다임실현을 위해서 보다 정확하고 빠른 진단기술이 절실히 요구되고 있다. 이를 실현하기 위한 대안으로 나노기술이 접목된 고감도 분자영상 관련 연구들이 활발히 진행되고 있다. 본 총설에서는 LDH 나노입자를 기반으로 하는 바이오 이미징 시스템의 개발동향에 관하여 소개하고 바이오 이미징에 적합한 나노소재의 구조 및 합성 방법에 대하여 설명하였다. 또한 임상 의학에서 현재 많이 사용되고 있는 형광을 이용한 광학영상, 자기공명영상(MRI), 핵의학영상(PET), 컴퓨터 단층 촬영(CT) 등 다양한 분야에서 어떻게 LDH 나노입자를 이용하여 나노 프로브 개발을 할 수 있는지 연구사례를 기술하면서 나노기술과 첨단영상기술이 융합된 획기적인 고감도 나노 바이오 이미징 시스템 개발 및 그 잠재력에 대하여 전망해 보았다.
      번역하기

      Layered double hydroxides (LDHs) 나노입자는 특유의 층상형 결정구조에서 기인된 물리화학적 물성 및 생체친화성을 바탕으로 나노-바이오 분야에서 주목을 받고 있다. 바이오 이미징은 질병의 진단...

      Layered double hydroxides (LDHs) 나노입자는 특유의 층상형 결정구조에서 기인된 물리화학적 물성 및 생체친화성을 바탕으로 나노-바이오 분야에서 주목을 받고 있다. 바이오 이미징은 질병의 진단과 치료(테라노스틱스, theranostics=therapy+diagnosis)에 다양하게 활용될 수 있는 핵심적인 분야로 차세대 맞춤의학으로의 새로운 패러다임실현을 위해서 보다 정확하고 빠른 진단기술이 절실히 요구되고 있다. 이를 실현하기 위한 대안으로 나노기술이 접목된 고감도 분자영상 관련 연구들이 활발히 진행되고 있다. 본 총설에서는 LDH 나노입자를 기반으로 하는 바이오 이미징 시스템의 개발동향에 관하여 소개하고 바이오 이미징에 적합한 나노소재의 구조 및 합성 방법에 대하여 설명하였다. 또한 임상 의학에서 현재 많이 사용되고 있는 형광을 이용한 광학영상, 자기공명영상(MRI), 핵의학영상(PET), 컴퓨터 단층 촬영(CT) 등 다양한 분야에서 어떻게 LDH 나노입자를 이용하여 나노 프로브 개발을 할 수 있는지 연구사례를 기술하면서 나노기술과 첨단영상기술이 융합된 획기적인 고감도 나노 바이오 이미징 시스템 개발 및 그 잠재력에 대하여 전망해 보았다.

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      다국어 초록 (Multilingual Abstract)

      Layered double hydroxides (LDHs) nanoparticles have emerged as novel nanomaterials for bio-imaging applications due to its unique layered structure, physicochemical properties, and good biocompatibility. Bio-imaging is one of the most important fields for medical applications in clinical diagnostics and therapeutics of various diseases.
      Enhanced diagnostic techniques are needed to realize new paradigm for next-generation personalized medicine through nanoscale materials. When nanotechnology is introduced into bio-imaging system, nanoparticle probes can endow imaging techniques with enhanced ability to obtain information about biological system at the molecular level. In this review, we summarize structural features of LDH nanoparticles with current issues of bio-imaging system. LDH nanoparticle probes are also discussed through in vitro as well as in vivo studies in various bio-imaging techniques including fluorescence imaging, magnetic resonance imaging (MRI), positron emission tomography (PET), and computed X-ray tomography (CT), which will have the potential in the development of the advanced nanoparticles with high sensitivity and selectivity.
      번역하기

      Layered double hydroxides (LDHs) nanoparticles have emerged as novel nanomaterials for bio-imaging applications due to its unique layered structure, physicochemical properties, and good biocompatibility. Bio-imaging is one of the most important fields...

      Layered double hydroxides (LDHs) nanoparticles have emerged as novel nanomaterials for bio-imaging applications due to its unique layered structure, physicochemical properties, and good biocompatibility. Bio-imaging is one of the most important fields for medical applications in clinical diagnostics and therapeutics of various diseases.
      Enhanced diagnostic techniques are needed to realize new paradigm for next-generation personalized medicine through nanoscale materials. When nanotechnology is introduced into bio-imaging system, nanoparticle probes can endow imaging techniques with enhanced ability to obtain information about biological system at the molecular level. In this review, we summarize structural features of LDH nanoparticles with current issues of bio-imaging system. LDH nanoparticle probes are also discussed through in vitro as well as in vivo studies in various bio-imaging techniques including fluorescence imaging, magnetic resonance imaging (MRI), positron emission tomography (PET), and computed X-ray tomography (CT), which will have the potential in the development of the advanced nanoparticles with high sensitivity and selectivity.

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      참고문헌 (Reference)

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      10 Kurreck, J., "RNA Interference : From Basic Research to Therapeutic Applications" 48 : 1378-1398, 2009

      1 Cha, B. G., "WIREs Nanomed Nanobiotechnol" e1515-, 2018

      2 Ahrens, E. T., "Tracking Immune Cells In Vivo Using Magnetic Resonance Imaging" 13 : 755-763, 2013

      3 Oh, J. M., "The Effect of Synthetic Conditions on Tailoring the Size of Hydrotalcite Particles" 151 : 285-291, 2002

      4 Wang, X., "Synthesis, Characterization, and Photoluminescent Properties of (La0.95Eu0.05)2O2SO4 Red Phosphors with Layered Hydroxyl Sulfate as Precursor" 603 : 28-34, 2014

      5 Wei, P. R., "Synthesis of Chitosan-coated Near-infrared Layered Double Hydroxide Nanoparticles for in vivo Optical Imaging" 22 : 5503-, 2012

      6 Wei, P. R., "Synthesis and Characterization of Chitosan-Coated Near-Infrared (NIR)Layered Double Hydroxide-Indocyanine Green Nanocomposites for Potential Applications in Photodynamic Therapy" 16 : 20943-20968, 2015

      7 Cheon, J., "Synergistically Integrated Nanoparticles as Multimodal Probes for Nanobiotechnology" 41 : 1630-1640, 2008

      8 Yoon, Y. S., "Surface Modification of Exfoliated Layered Gadolinium Hydroxide for the Development of Multimodal Contrast Agents for MRI and Fluorescence Imaging" 19 : 3375-3380, 2009

      9 Shin, T. H., "Recent Advances in Magnetic Nanoparticle-based Multi-modal Imaging" 44 : 4501-4516, 2015

      10 Kurreck, J., "RNA Interference : From Basic Research to Therapeutic Applications" 48 : 1378-1398, 2009

      11 Michalet, X., "Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics" 307 : 538-544, 2005

      12 Medintz, I. L., "Quantum Dot Bioconjugates for Imaging, Labelling and Sensing" 4 : 435-446, 2005

      13 Li, B., "Novel Theranostic Nanoplatform for Complete Mice Tumor Elimination via MR Imaging-guided acid-enhanced photothermo-/chemo-therapy" 177 : 40-51, 2018

      14 Cao, Y. W., "Nanoparticles with Raman Spectroscopic Fingerprints for DNA and RNA Detection" 297 : 1536-1540, 2002

      15 Lee, D. H., "Multifunctional Nanoparticles for Multimodal Imaging and Theragnosis" 41 : 2656-2672, 2012

      16 Yang, J., "Multifunctional Magneto‐polymeric Nanohybrids for Targeted Detection and Synergistic Therapeutic Effects on Breast Cancer" 46 : 8836-8839, 2007

      17 Peng, L., "Monolayer Nanosheets with an Extremely High Drug Loading toward Controlled Delivery and Cancer Theranostics" 30 : 1707389-, 2018

      18 Weissleder, R., "Molecular Imaging in Cancer" 312 : 1168-1171, 2006

      19 Zuo, H., "MnAl Layered Double Hydroxide Nanoparticles as a Dual-Functional Platform for Magnetic Resonance Imaging and siRNA Delivery" 23 : 14299-14306, 2017

      20 Huang, G., "Manganese-iron Layered Double Hydroxide: a Theranostic Nanoplatform with pH-Responsive MRI Contrast Enhancement and Drug Release" 5 : 3629-3633, 2017

      21 Li, B., "Manganese-Based Layered Double Hydroxide Nanoparticles as a T1 -MRI Contrast Agent with Ultrasensitive pH Response and High Relaxivity" 29 : 1700373-, 2017

      22 Laurent, S., "Magnetic Iron Oxide Nanoparticles : Synthesis, Stabilization, Vectorization, Physicochemical Characterizations, and Biological Applications" 108 : 2064-2110, 2008

      23 Mishra, G., "Layered Double Hydroxides : A Brief Review from Fundamentals to Application Asevolving Biomaterials" 153 : 172-186, 2018

      24 Oh, J. M., "LDH Nanocontainers as Bio-reservoirs and Drug Delivery Carriers" 6 : 200-217, 2012

      25 Kim, T. H., "Isomorphous Substitution of Divalent Metal Ions in Layered Double Hydroxides Through a Soft Chemical Hydrothermal Reaction" 43 : 10430-, 2014

      26 Chung, H. E., "Intracellular Trafficking Pathway of Layered Double Hydroxide Nanoparticles in Human Cells: Size-dependent Cellular Delivery" 65-66 : 24-30, 2012

      27 Choy, J. H., "Intercalative Nanohybrids of Nucleoside Monophosphates and DNA in Layered Metal Hydroxide" 121 : 1399-1400, 1999

      28 Na, H. B., "Inorganic Nanoparticles for MRI Contrast Agents" 21 : 2133-2148, 2009

      29 Huang, H. C., "Inorganic Nanoparticles for Cancer Imaging and Therapy" 155 : 344-357, 2011

      30 Oh, J. M., "Inorganic Metal Hydroxide Nanoparticles for Targeted Cellular Uptake Through Clathrin-Mediated Endocytosis" 4 : 67-73, 2009

      31 Choy, J. H., "Inorganic Layered Double Hydroxides as Nonviral Vectors" 39 : 4041-4045, 2000

      32 Oh, J. M., "Inorganic Drug‐delivery Nanovehicle Conjugated with Cancer ‐Cell‐Specific Ligand" 19 : 1617-1624, 2009

      33 Ashton, J. R., "In vivo Small Animal Micro-CT Using Nanoparticle Contrast Agents" 6 : 2015

      34 Qian, X., "In Vivo Tumor Targeting and Spectroscopic Detection with Surface-Enhanced Raman Nanoparticle Tags" 26 : 83-90, 2007

      35 Mei, X., "Hydrotalcite Monolayer Toward High Performance Synergistic Dual-modal Imaging and Cancer Therapy" 165 : 14-24, 2018

      36 Caravan, P., "Gadolinium(III)Chelates as MRI Contrast Agents : Structure, Dynamics, and Applications" 99 : 2293-2352, 1999

      37 Kim, S. Y., "Gadolinium (III) Diethylenetriamine Pentaacetic Acid/Layered Double Hydroxide Nanohybrid as Novel T1-Magnetic Resonant Nanoparticles" 8 : 5181-5184, 2008

      38 Yang, J., "Fluorescent Magnetic Nanohybrids as Multimodal Imaging Agents for Human Epithelial Cancer Detection" 29 : 2548-2555, 2008

      39 Xu, Z. P., "Enhancement of Relaxivity Rates of Gd-DTPA Complexes by Intercalation into Layered Double Hydroxide Nanoparticles" 13 : 2824-2830, 2007

      40 Arratia-Quijada, J., "Dysprosium-containing Layered Double Hydroxides Nanoparticles Intercalated with Biologically Active Species as an Approach for Theranostic Systems" 203 : 7-12, 2016

      41 Choy, J. H., "Clay Minerals and Layered Double Hydroxides for Novel Biological Applications" 36 : 122-132, 2007

      42 Shi, S., "Chelator-Free Labeling of Layered Double Hydroxide Nanoparticles for in Vivo PET Imaging" 5 : 2015

      43 Oh, J. M., "Cellular Uptake Mechanism of an Inorganic Nanovehicle and Its Drug Conjugates:Enhanced Efficacy Due To Clathrin-Mediated Endocytosis" 17 : 1411-1417, 2006

      44 Choy, J. H., "Cellular Uptake Behavior of [γ32P] Labeled ATP-LDH Nanohybrids" 11 : 1671-1674, 2001

      45 Park, D. H., "Biodegradable Inorganic Nanovector: Passive versus Active Tumor Targeting in siRNA Transportation" 55 : 4582-4586, 2016

      46 Choi, J., "Biocompatible Heterostructured Nanoparticles for Multimodal Biological Detection" 128 : 15982-15983, 2006

      47 Park, D. H., "Bio-Layered Double Hydroxides Nanohybrids for Theranostics Applications" 166 : 137-174, 2015

      48 Guan, S., "A Supramolecular Material for Dual-modal Imaging and Targeted Cancer Therapy" 165 : 297-303, 2017

      49 Choi, J. S., "A Hybrid Nanoparticle Probe for Dual-modality Positron Emission Tomography and Magnetic Resonance Imaging" 47 : 6259-6262, 2008

      50 Wang, L., "A Gd-doped Mg-Al-LDH/Au Nanocomposite for CT/MR Bimodal Imagings and Simultaneous Drug Delivery" 34 : 3390-3401, 2013

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      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2013-01-01 평가 등재 1차 FAIL (등재유지) KCI등재
      2010-12-02 학술지명변경 한글명 : 화학공학 -> Korean Chemical Engineering Research(HWAHAK KONGHAK) KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2009-08-25 학술지명변경 외국어명 : Korean Chem. Eng. Res. -> Korean Chemical Engineering Research KCI등재
      2008-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2007-09-27 학회명변경 영문명 : The Korean Institute Of Chemical Engineers -> The Korean Institute of Chemical Engineers KCI등재
      2006-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2004-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2001-07-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      1999-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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