Increasing antiviral drug resistance, especially multi-drug resistance (MDR) is one of the main problem in the management of chronic viral hepatitis B (CHB). To prevent or treatment of antiviral drug resistance, it should be based on the precise clini...
Increasing antiviral drug resistance, especially multi-drug resistance (MDR) is one of the main problem in the management of chronic viral hepatitis B (CHB). To prevent or treatment of antiviral drug resistance, it should be based on the precise clinical and regular virologic monitoring as well as an early change or add on with drug with higher genetic barrier without sharing cross resistance profile. This topic review will summarize the clinical issues related to antiviral resistance of hepatitis B, including mechanism of resistance, treatment, and prevention strategy.