RISS 검색 - 국내학술지논문 상세보기

다국어 초록 (Multilingual Abstract)

Genital HPV infection is the most common sexually transmitted infection, but the majority of infections are self-limited. However, persistent infection with high-risk types can cause cervical cancer in women, which is the most common female genital cancer in Korea. In addition, HPV infection is the cause of genital warts and is associated with other anogenital cancers. The HPV vaccine is composed of the HPV L1 protein, the major capsid protein of HPV. Expression of the L1 protein in yeast using recombinant DNA technology produces noninfectious virus-like particles (VLP) that resemble HPV virions. The quadrivalent HPV vaccine is a mixture of four HPV type-specific VLPs prepared from the L1 proteins of HPV 6, 11, 16, and 18 combined with an aluminum adjuvant. Clinical trials indicate that the vaccine has high efficacy in preventing persistent HPV infection, cervical cancer precursor lesions, vaginal and vulvar cancer precursor lesions, and genital warts caused by HPV types 6, 11, 16, or 18 among females who have not already been infected with the respective HPV type. The recommended age for primary vaccination of Korean females is 15-17 years, considering sexual debut and duration of protection of the vaccine. Vaccine can be administered as young as age 9 years. Catch-up vaccination is recommended for females aged 18-26 years who have not been previously vaccinated. Vaccination is not a substitute for routine cervical cancer screening, and vaccinated females should have cervical cancer screening as recommended.

국문 초록 (Abstract)

목적：이 연구는 상피성 난소암에 있어서 c-Met의 발현을 알아보기 위함이다. 연구 방법：상피성 난소 종양 50개의 파라핀 포매괴를 c-Met에 대해 면역조직염색을 시행하였다. 그 후 c-Met의 ...

목적：이 연구는 상피성 난소암에 있어서 c-Met의 발현을 알아보기 위함이다.
연구 방법：상피성 난소 종양 50개의 파라핀 포매괴를 c-Met에 대해 면역조직염색을 시행하였다. 그 후 c-Met의 발현을 조직형, 종양 크기, 그리고 병기 등의 임상병리학적 변수들과 연관시켜 보았다.
결과：c-Met의 발현이 전체 50예 중 29예 (58%)에서 관찰되었으나 종양의 조직형, 종양크기 및 병기등의 임상병리학적 변수들은 c-Met의 발현과 연관성이 없었다.
결론：c-Met의 발현은 진행된 상피성 난소암의 예후 인자로 쓰일 가능성이 있으나 이를 임상에서 응용하기 위해서는 더 많은 인구집단을 대상으로 한 연구가 행해져야 한다.

참고문헌 (Reference)

1 Pisters L, "c-Met proto-oncogene expression in benign and malignant human prostate tisues" 154 : 293-298, 1995

2 Medico E, "The tyrosine kinase receptors Ron and Sea control scatering and morphogenesis of liver progenitor cells in vitro" 7 : 495-504, 1996

3 Berchuck A, "The role of peptide growth factors in epithelial ovarian cancer" 255-62, obstetgynecol1990;75

4 Lamszus K, "Scatter factor stimulates tumor growth and tumor angiogenesis in human breast cancers in the mamary fat pads of nude mice" 76 : 339-353, 1997

5 Stoker M, "Scatter factor is a fibroblast-derived modulator of epithelial cell moti-lity" 939-42, nature1987;327

6 Hartman LC, "Prognostic significance of p53 immunostaing in epithelial ovarian cancer" 64-9, jclinoncol1994;12

7 Yo Y, "Potential role of hepatocyte growth factor in the maintenance of renal structure anti-apoptotic action of HGF on epithelial cells" 1128-38,

8 Kimig R, "Multivariate analysis of the prognostic significance of DNA-ploidy and S-phase fraction in ovarian cancer determined by flow cytometry folowing detection of cytokeratin-labeled tumor cels" 84 : 21-31, 2002

9 Goke M, "Intestinal fibroblasts regulate intestinal epithelial cell proliferation via hepa-tocyte growth factor" 274 : 809-818, 1998

10 Sui L, "Implication of malignancy and prognosis of p27 (kip1), Cyclin E, and Cdk2 expression in epithelial ovarian tumors" 83 : 56-63, 2001