단순남성임질 치료에 Kanamycin 및 Probenecid/Fortified Procaine Penicillin G (6 Mu) 병용요법과 Spectinomycin 단독요법의 비교 : Kanamycin plus Probenecid/Fortified Procaine Penicillin G (6 Mu) vs. Spectinomycin = Comparision of Treatment Regimens for Uncomplicated Gonococcal Urethritis

다국어 초록 (Multilingual Abstract)

From April 1 to October 9, 1985, 289 patients with uncomplicated gonococcal urethritis, seen at the Choong-Ku Public Health Center VD Clinic, were entered into this study. The diagnosis of gonococcal infection and the test of cure were made by the results of culture and Gram staining of urethral smear.
The patients were randomly divided into group A and group B, which consisted of 142 and 147, respectively.
In group A, kanamycin(KM) 2.0 gm im plus probenecid(BEN) 1.0 gm PO/fortified procaine penicillin G(FPPG) 6 Mu im regimen gave two(1.8%) treatment failures of 110 followed patients.
In group B, spectinomycin 2.0 gm im regimen gave one(0.9%) treatment failure of 112 followed patients.
The failure rates in both groups were satisfactorily low and not significantly different.
The failure rates of PPNG urethritis in group A and in group B were 3.9% and 2.0%, respectively and th difference was not significant.
There was no significant difference in the rates of post-gonococcal urethritis between two groups.
It is suggested that KM 2.0 gm im plus BEN 1.0 gm PO/FPPG 6 Mu regimen can be used as the first line treatment for uncomplicated gonococcal urethritis in the view of inexpensivenss and efficacy.
It is further suggested that in the event KM plus FPPG(6 Mu) regimen will not meet the increasing resistance of Neisseria gonorrhoeae to penicillins, aqueous crystalline penicillin G, 8 Mu more can be substituted for FPPG.