자궁경부아에서 종양표지물 SCC, CET, TPA의 유용성 = The Clinical Significance of SCC, CEA and TPA as Tumor Markers in Cervical Cancer

다국어 초록 (Multilingual Abstract)

The clinical role of tumor markers to detect the extent of tumor invasion and recurrence in cervical cancer has been debated. To evaluate the clinical significance of SCC, CEA and TPA as tumor markers in cervical, we studied 744 patients with cervical cancer from June 1990 to May 1994. The cut-off values of SCC, CEA and TPA were 1.5 ng/ml, 4.5 ng/mi and 110 U/ I respectively. Followings were the results.
1. The serum concentration and positive rates of SCC before therapy(567 cases) were 3,0±7.0ng/ml(40.4%) for stage I,8.7±13.9 ng/ml(71.6%) for stage II, 10.8±14.7 ng/ml(85.7%) for stage III, 23.9±24.3 ng/ml(94.7%) for stage IV, and 13.4±19,1 ng/ml(75.0% ) for recurrent cancer. It was increased with advancing clinical stage(p$lt;0.01).
2. The serum levels and positive rate of CEA before therapy(627cases) were 3.4±4.3 ng/ml (18% ) for stage I, 7.1±12.3 ng/ml(37.2%) for stage II, 8.4+9.6 ng/ml(57.9%) for stage III, 15.4±22.2 ng/ml(52.6%) for stage IV, and 10.3±16.2 ng/ml(46.4%) for recurrent cancer. It was increased with advancing clinical stage from stage Ito stage III(p$lt;0.01).
3. The serum concentration and positive rate of TFA before therapy(301cases) were 51.7±53.8 U/l(9.5%) for stage I, 105.3±108.8 U/l(32.3%) for stage II, 186.3%±159.8 U/l(50%) for stage III, 191.3±1062 U/1(63.6%) for stage IV, and 135.4+117.0 U/l(46.4% ) for recurrent cancer. It was increased with advancing clinical stage(p$lt;0.01).
4. In 64 patients{24.2%) with lymph node invasion of 265 patients treated by operation, the mean serum levels of SCC, CEA and TPA were higher than lymph node negative group(p$lt;0.05).
5. The serum levels of SCC and CKA after therapy were 82.8% in sensitivity. 94.3% in specificity, 67.9% in positive predictive value, 97.4% in negative predictive value.