악성 종양환자의 혈청，흉막참출액 및 뇨의 Insulin-like growth factor-I, 2 의 발현 = The expression of insulin-like growth factor*-!, II in pleural effusion： serum, and urine of the patients with malignant tumor

다국어 초록 (Multilingual Abstract)

Purpose : Insulin-like growth factors are known to be involved in cell cycle and also in the proliferation of cancer cells. In the study，we investigated the concentration on IGFs of pleural effusion，serum, and urine in both malignant tumor group and non-malignant tumor group. Materials & methods : Among 37 patients with pleural effusion on plain chest X-ray, 28 patients who were diagnosed having either lung cancers or other malignant tumors were designed as malignant tumor group and the remaining 9 patients were used as control group. The pleural effusion，serum, and urine were sampled for both groups and quantitative analysis was done using immunoradiometric assay. Results : The levels of serum IGF-I in malignant tumor group and control group were 86.6±68(6(ng/ml) and 80,5 土 117.51 respectively but those results were within normal limits, with malignant tumor group showing higher levels with no statistical difference. The levels of IGF-1 from pleural effusion in the malignant tumor group were higher than the control group with no statistical difference(l 12,9土59,96 vs 97.1 土45.07). The levels of IGF-II from serum and pleural effusion in the control group were higher than the malignant tumor group with no statistical difference(狀rum:359.8 土275.23 vs 344,4 土 138.58, pleural effusion:275.4 土 202.03 vs 162.7土 55,86 respectively), but the level of IGF-I from the pleural effusion of lung cancer patients，adenocarcinoma( 155.9 土 53.78) showed higher than small cell carcinoma(73,4 土51.60) with statistical difference(p<0.03). In comparision of pleural effusion between non-small cell carcinoma and small cell carcinoma，non-small cell carcinoma showed higher values of IGF-I，with statistical difference(p<0‘04). Conclusions : The values of IGF-IJI from pleural effusion，serum, and urine did not show significant differences between malignant tumor and control groups. Among lung cancer patients, the values of IGF-IJI from pleural effusion of non-small cell carcinoma were higher than those of small cell carcinoma in pleural effusion and serum respectively. IGF-1 showed higher levels in pleural effusion and IGF-II shows higher levels in serum, IGF-IJI are similar in structures but differs in their expressions. Clinically, it is very important for chemotherapy and further treatment that differentiation between small cell carcinoma and non-small cell carcinoma in lung cancer patients. Especially, in lung cancer patients with pleural effusion it is important because the treatment is delayed due to the difficulty of lung tissue biopsy. So according to the results of the levels of IGF-IJI from pleural effusion in non smalt cell lung carcinoma were higher than small cell carcinoma，I think IGF-IJI would be a marker of the differentiation,