서울대학교병원에서의 희귀의약품 사용현황 분석 = Analysis of Orphan Drug Use in Seoul National University Hospital.

다국어 초록 (Multilingual Abstract)

Orphan drugs are used for rare disease, the number of domestic patients suffering from such disease being no more than 20,000 or for disease for which no treatment or no alternative medicine is yet. Orphan drugs are supplied by pharmaceutical companies or by Korea Orphan Drug Center(KODC). Presently, there are total 93 kinds of orphan drugs designated as such by the relevant laws, and Seoul National University Hospital(SNUH) has 49 kinds(53%) of them(as of June 2003). The purpose of this study was to analyze usage of orphan drugs prescribed by SNUH and to improve of the related pharmacy services for effective treatment of patents of the rare disease.
We analyzed usage of orphan drugs inside and outside of SNUH, gender of patients, related clinical departments and frequency of use for the period from Jan. 2001 to June 2003. For the purpose, we used KODC data of use by patients in SNUH.
The use of orphan drugs in SNUH sharply increased from 2000 through 2001 and was steadily increasing since then. The ratio of usage inside to outside SNUH was 92 to 8(as of June 2003). The clinical department that prescribed the orphan drugs most frequently was the internal medicine department(74~84%). The most frequently used drugs were antiviral agents(74%, oral drug) and antineoplastics(58%, injectable drug).
KODC supplied 6 kinds of orphan drugs in 2002 and 4 kinds in the first half of 2003 to SNUH patients. The proportion of SNUH patients to the total patients who used orphan drugs supplied by KODC was very variable. (dantrolen 0.46% ~ ganciclovir 50.5%).