N/A
http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
https://www.riss.kr/link?id=A30005824
2001
-
500
SCOPUS,KCI등재,SCIE
학술저널
161-165(5쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Acebutolol (ABT) is almost absorbed after oral administration, but its bioavailability is reduced because of considerable first-pass metabolism in the gastrointestine and liver. The purpose of this study was to report the pharmacokinetic changes of AB...
Acebutolol (ABT) is almost absorbed after oral administration, but its bioavailability is reduced because of considerable first-pass metabolism in the gastrointestine and liver. The purpose of this study was to report the pharmacokinetic changes of ABT and its metabolite, diacetolol (DAT) after oral administration of acebutolol to control rabbits and rabbits with mild and severe folate-induced renal failure (FIRRs). Both of the area under the plasma concentration-time curve (AUC^0_∞) of ABT and DAT were significantly increased in mild (p<0.05) and severe FIRRs (p<0.01), but the AUC^0_∞ of DAT was more influenced than that of ABT in severe rabbits. There was a good correlation between serum creatinine and both of AUC^0_∞ of ABT and DAT. The elimination half-life of ABT and DAT was significantly prolonged in mild (p<0.05) and severe (p<0.01) FIRRs, but the half-life of DAT was more influenced than that of ABT in severe FIRRs. The results suggest that the dosage of acebutolol should be adjusted according to the degree of renal disorder on the base of the serum creatinine concentration.
세프테졸 부티로락톤 에스텔의 합성 및 생물약제학적 특성
프로게스테론과 시클로덱스트린류 간의 복합체 형성 및 수성 주사제 설계
[ P ( AA - co - PEGMM ) ] 공중합체 필름의 합성 및 물리화학적 특성