Magnetothermal Properties of Triethylene Glycol-Coated Cobalt-Zinc-Ferrite Nanoparticles for Magnetic Hyperthermia Applications

다국어 초록 (Multilingual Abstract)

Cobalt zinc ferrite (Co0:6Zn0:4Fe2O) nanoparticles were synthesized using a one-step hydrothermal method. Triethylene glycol (TREG) was used as a biocompatible coating material. The TREGcoated nanoparticles were spherical, with an average diameter of 9.82 nm. The Fourier-transform infrared spectra confirmed the presence of a TREG-coating on the surfaces of the nanoparticles.
The particles had a saturation magnetization of 84 emu/g and a coercivity of 32 Oe. The heating capability of the particles was evaluated using an induction system, and the heating curves for aqueous samples with various particle concentrations were obtained. An alternating magnetic field with an amplitude of 4.5 kA/m and a frequency of 216 kHz was applied to the samples. The optimal particle concentration in water for achieving the hyperthermia target temperature of 42 ◦C was 4.58 mg/mL. The specific absorption rate (SAR) of the 2-mg/mL sample was 83 W/g.
The linear relationship between the SAR and the square of the field strength was confirmed for a representative 10-mg/mL sample. These findings show that TREG-coated particles are suitable for magnetic hyperthermia applications owing to their superparamagnetic properties and high SAR values.

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