흰쥐의 파라쿼트 중독모델에서 폐손상에 대한 N-acetylcysteine과 Methylprednisolone의 효과 = Effectsof N-acetylcysteine and Methylprednisolone on Lung Injury in a Paraquat-Posioned Rat Model

다국어 초록 (Multilingual Abstract)

Background: This study evaluated the inhibitory effects of N-acetylcysteine(NAC) and methylprednisolone on lung injury in the paraquat-poisoned rat model.
Methods: Sixty rats were divided into four groups(n=15 in each group) accordingly to the drug administered : group I, only intraperitoneally injected paraquat (20 mg/kg); group II, intraperitoneally injected paraquat and NAC(300 mg/kg); group III, intraperitoneally injected paraquat and methylprednisolone(60 mg/kg); and group IV, intraperitoneally injected paraquat, NAC(300 mg/kg), and methylprednisolone(60 mg/kg). On the 7th day after injection, the survival rate of experimental rats and the positive area of collagen fiber in the injured lung stained by Masson's trichroms were evaluated.
Results: 1. There were no differences in the 7-day survival rates for the four groups. 2, The percent of collagen fiber for group II(6.3 ± 4.7%) was significantly decreased in comparison with that for group I (14.4±9.7%). 3. The percent of collagen fiber for Group III(13.2±5.9%) was not significantly different from that for group I(14.4±9.7%). 4. The percent of collagen fiber for Group IV(6.9±4.6%) was significantly decreased in comparison with that for group I, but was not different from that for group II.
Conclusion: These results suggest that NAC protects against pulmonary fibrosis in paraquat-poisoned rats whereas methylprednisolone does not protect against pulmonary fibrosis.

목차 (Table of Contents)

• Ⅰ.서론
• Ⅱ.대상과 방법
• 1.실험동물
• 2.실험군과 실험방법
• 3.병리 조직학적 검사
• 4.통계처리
• Ⅲ.결과
• 1.생존율
• 2.병리조직학적 결과
• Ⅳ.고찰
• Ⅴ.결론