폐경과 비만 여부에 따른 ghrelin, adiponectin, 유산소능력의 차이와 신체조성지표들 간의 관련성 = The Differences of Ghrelin, Adiponectin, and Aerobic Capacity by Menopause and Obesity and its Inter-Correlation with Body Composition Indexes

다국어 초록 (Multilingual Abstract)

capacity by menopause and obesity, and also to exam the inter-relationship among the above three factors and body composition indexes. Female subjects participated in this study and they were classified by BMII>30 and %BF>25% as normal weight and obesity groups, and by menopause state as pre-menopause and menopause groups. G1 is defined as pre-menopause and non-obese (44.1±5.6 yrs, n=10), G2 is as pre-menopause and obese (42.5±7.8 yrs, n=10), G3 is as menopause and non-obese (51.4±4.8 yrs, n=17), and G4 is as menopause and obese (54.0±3.6, n=18). VO2max was estimated as an aerobic capacity, and weight, BMI, %BF, WC, WHR were estimated as body composition indexes. Independent t-test was performed to compare the differences of aerobic capacity, ghrelin, and adiponectin by obesity and menopause state. Two-way ANOVA was utilized to compare ghrelin, adiponectin, and VO2max differences by groups. Also, peason`s correlations were used in total subjects to produce the inter-correlations between ghrelin, adiponectin and VO2max, body composition indexes. As results, adiponectin was significantly different by obesity. VO2max was significantly different between G2 and G3. There were significant correlation between ghrelin and VO2max. Also, significant correlations between adiponectin and BMI, body weight, %BF, waist circumference, waiast & hip ratio. These results indicate that management of cardiovascular risk factors, diponectin, would be possible by monitoring body composition indexes in menopaused woman. Furthermore, enhancing aerobic capacity can be used as therapy strategy in order to decrease cardiovascular risk.

참고문헌 (Reference)

1 ACSM's Guidelines for Exercise Testing and Prescription, Lippincott Williams & Wilkins 74-, 2006

2 Hansen, T. K, "Weight loss increases circulating levels of ghrelin in human obesity" 56 : 203-206, 2002

3 Turcato, E, "Waist circumference and abdominal sagittal diameter as surrogates of body fat distribution in the elderly:Their relation with cardiovascular risk factors.International Journal of Obesity and Related Metabolic" 24 : 1005-1010, 2000

4 James, P. T, "The worldwide obesity epidemic" 9 (9): 228S-233S, 2001

5 Yamauchi, T, "The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity" 7 : 941-946, 2001

6 Broglio, F, "The endocrine response to ghrelin as function of gender and age in humans" 3-556, 2002

7 Ariyasu, H, "Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immuno-reactivity levels in humans" 86 : 4547-4571, 2001

8 Yuan, G, "Serum CRP levels are equally elevated in newly diagnosed type 2 diabetes and impaired glucose tolerance and related to adiponectin levels and insulin sensitivity"

9 Shiiya, T, "Plasma ghrelin levels in lean and obese hunmans and the effect of glucose on ghrelin secretion" 87 (87): 240-244, 2002

10 Erdmann, J, "Plasma ghrelin levels during exercise - effects of intensity and" 143 : 127-135, 2007

11 Rigamonti, A. E, "Plasma ghrelin concentrations in elderly subjects: comparison with anorexic and obese patients" 175 (175): R1-R5, 2002

12 Ravussin, E, "Plasma ghrelin concentration and energy balance: overfeeding and negative energy balance studies in twins" 86 : 4547-4551, 2001

13 Pistola, T, "Plasma adiponectin levels and risk of myocardial infarction in men" 291 : 1730-1763, 2004

14 Jürimäe, J, "Plasma adiponectin concentration in healthy pre- and postmenopausal women: relationship with body composition, bone mineral, and metabolic variables" 293 (293): E42-E47, 2007

15 Arita, Y, "Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity" 257 : 79-83, 1999

16 Iwamoto, I, "Menopausal status influences the relationship between serum ghrelin levels and fat mass in healthy women" 28 : 405-409, 2005

17 Foster-Schubert, K, "Human plasma ghrelin levels increase during a one-year exercise program" 90 : 820-825, 2005

18 Nagaya, M, "Hemodynamic and hormonal effects of human ghrelin in healthy volunteer" 280 : R1483-R1487, 2001

19 Locatelli, V, "Growth hormone-independent cardioprotective effects of hexarelin in the rat" 140 : 4024-4031, 1999

20 Shintani, M, "Ghrelin,an endogenous growth hormone secretagogue is a novel orexigenic peptid that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway" 50 : 227-232, 2001

21 Nagaya, N, "Ghrelin, a novel growth hormone releasing peptide, in the treatment of chronic heart failure" 114 : 71-77, 2003

22 Wren, A. M, "Ghrelin enhances appetite and increases food intake in humans" 86 : 5992-, 2001

23 Holdstock, C, "Ghrelin and adipose tissue regulatory peptides: effect of gastric bypass surgery in obese humans" 88 : 3177-3183, 2003

24 Marcell, T. J, "Exercise training is not associated with improved levels of C-reactive protein or adiponectin" 54 : 533-541, 2005

25 Killokoski, E, "Estrogen replacement therapy increases plasma ghrelin levels" 90 : 2954-2963, 2005

26 Monzillo, L. U, "Effect of lifestyle modification on adipokine levels in obese subject with insulin resistance" 11 : 1048-1054, 2003

27 Katsuki, A, "Circulating levels of active ghrelin is associated with abdominal adiposity, hyperinsulinemia and insulin resistance in patients with type 2 diabetes mellitus" 151 : 573-577, 2004

28 Tschöp, M, "Circulating ghrelin levels are decreased in human obesity" 50 (50): 707-709, 2001

29 Leidy, H. J, "Circulating ghrelin is sensitive to changes in body weight during a diet and exercise program in normal-weight young women" 89 : 2659-2664, 2004

30 Nagaya, N, "Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure" 104 : 1430-1435, 2001

31 Sowers, M. F. R, "Change in adipocytokines and ghrelin with menopause.The European Menopause" 59 : 149-157, 2008

32 Anker, S. D, "Cardiac cachexia: a syndrome with impaired survival and immune and neuroendocrine activation" 115 : 836-847, 1999

33 Nishizawa, H, "Androens decrease plasma adiponectin, and insulin-sensitizing adipocyte derived protein" 51 : 2734-2741, 2002

34 Pajavani, U. B, "Adiponectin: systemin contributor to insulin sensitivity" 3 : 207-213, 2003

35 Kumada, M, "Adiponectin specifically increased tissue inhibitor of metalloprotenase-1 through interleukin-10 expression in human macrophages" 109 : 2046-2049, 2004

36 Ouchi, N, "Adipocyte-derived plasma protein, adiponectin, suppress lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages" 103 : 1057-1063, 2001

37 Schmidt, A, "Acute exercise has no effect on ghrelin plasma concentrations" 36 : 174-177, 2004

38 Berg, A. H, "ACR30/adiponectine: an adipokine regulating glucose and lipid metabolism" 13 : 84-89, 2002