HBV : Prevalence and Genotype Distribution of Hepatitis B, C and D Viruses among Patients with Chronic Liver Diseases of Mongolia = HBV : Prevalence and Genotype Distribution of Hepatitis B, C and D Viruses among Patients with Chronic Liver Diseases of Mongolia

다국어 초록 (Multilingual Abstract)

Background/aims: Mongolia is known for its high endemicity for HBV, HCV, and HDV infections among apparently healthy populations. However there are little or no data on the prevalence and genotype distribution of HBV, HCV and HDV among patients with chronic liver diseases in Mongolia. Materials and methods: Serum samples obtained in 2009 from 207 patients (51.0±1.9 years) including those chronic hepatitis (n=90), liver cirrhosis (n=41), and HCC (n=76) were tested for serological and molecular markers of HBV, HCV, and HDV infections. Results: Of the 207 patients, 144 (69.6%), 106 (51.2%), and 117 (56.5%) tested positive for HBsAg and HBV DNA , HCV RNA, and HDV RNA, respectively. Collectively, 172 patients (83.1%) were viremic for one or more of these viruses, including dual viremia of HBV/HDV (26.6%) or HBV/HCV (7.7%) and triple HBV/HCV/HDV viremia (30.0%). Of note, triple ongoing infection was significantly more frequent among patients with HCC than among those with chronic hepatitis (63.2%) vs. 14.4%, P≤0.0001). The distribution of HBV genotypes among the 116 HBV-viremic patients was: A (0.9%), B (0.9%), C (6.0%), D (88.8%), and C plus D(3.4%). All 117 HDV isolates were classified into genotype 1. The 106 HCV RNA positive samples were typed as genotype 1b (92.5%). Conclusions: The present study revealed that ongoing dual or triple infection of HBV, HCV and HDV is highly prevalent among patients with chronic liver diseases of Mongolia.