비강내 누낭비강문합술시 시행한 양막충전술의 단기 임상 결과

다국어 초록 (Multilingual Abstract)

`Purpose: To evaluate the short-term surgical results of Merocel? nasal packing wrapped with human amniotic membrane on the internal ostium during endonasal dacryocystorhinostomy (DCR). Methods: Sixty patients who underwent endonasal DCR to treat nasolacrimal duct obstruction from October 2005 to April 2006 were enrolled in this prospective study. The patients were divided into two groups: 30 patients treated with Merocel? packing wrapped with amniotic membrane were assigned to group 1, and the remaining 30 patients were assigned to group 2. During the follow-up period, the authors evaluated surgical wound healing, the incidence of granuloma, and the patency of the internal ostium. Results: Success rates at 6 months after surgery were higher in group 1 than in group 2, but these rates showed no statistically significant difference between the two groups (group 1: 93.3%, group 2: 86.7%, p=0.67). The time for mean wound healing in group 1 was significantly shorter than that in group 2 (group 1: 4.8±1.5 weeks, group 2: 7.3±1.5 weeks, p<0.001). The incidence of granuloma in group 1 was lower than that in group 2 at 2 months after surgery (group 1: 13% (4/30), group 2:33% (14/30), p=0.04). However, there was no difference of granuloma formation between the two groups at 6 months postoperatively (group 1: 33% (11/30), group 2: 46% (14/30)). Conclusions: The authors believe that the use of Merocel? packing wrapped with amniotic membrane after endonasal DCR might decrease postoperative inflammation, accelerate wound healing, and decrease granuloma formation in the early postoperative period.`

참고문헌 (Reference)

1 한영근, "군날개절제술 후 발생한 괴사성공막염에 대한 면역억제제를 이용한 치료" 대한안과학회 44 (44): 272-277, 2003

2 Kim JC, "Transplantation of preserved human amniotic membrane for surface reconstruction in severely damaged rabbit corneas" 14 : 473-484, 1995

3 Shimazaki J, "Transplantation of amniotic membrane and limbal autograft for patients with recurrent pterygium associated symblephron" 82 : 235-240, 1998

4 Fujishima H, "Trabeculectomy with the use of amniotic membrane for uncontrollable glaucoma" 29 : 428-431, 1998

5 Kurpakus MA, "The role of the basement membrane in differential expression of keratin proteins in epithelial cells" 150 : 243-255, 1992

6 Lee TS, "The relationship between rate of wound healing and success rate after endonasal laser-drill assisted dacryocystorhinostomy" 40 : 2969-2974, 1999

7 Woo HM, "The effect of amniotic membrane graft on the inhibition of corneal haze in rabbit" 40 : 2385-2394, 1999

8 Shin HY, "The comparision of surgical results of endonasal dacryocystorhinostomy in childen and adults" 47 : 877-882, 2006

9 Tsubota K, "Surgical reconstruction of the ocular surface in advanced ocular cicatrical pemphigoid and Stevens-Johnson syndrome" 122 : 38-52, 1996

10 Solomon A, "Suppression of interleukin 1α and interleukin 1β in human limbal epithelial cells cultured on the amniotic membrane stromal matrix" 85 : 444-449, 2001

11 Lee HC, "Success rate of endonasal dacryocystorhinostomy" 37 : 211-218, 1996

12 Davis JW, "Skin transplantation with a review of 550 cases at the Johns Hopkins Hospital" 15 : 307-, 1910

13 Wang MX, "Reduction in corneal haze and apoptosis by amniotic membrane matrix in excimer laser photoablation in rabbits" 27 : 310-319, 2001

14 De Rotth A, "Plastic repair of conjunctival defects with fetal membrane" 23 : 522-525, 1940

15 Alsagoff Z, "Necrotising scleritis after bare sclera excision of pterygium" 84 : 1050-1052, 2000

16 Hanada K, "Multilayered amniotic membrane transplantation for severe ulceration of the cornea and sclera" 131 : 324-331, 2001

17 Dresner SC, "Lacrimal drainage system inflammatory masses from retained silicone tubing" 98 : 609-613, 1984

18 Hao Y, "Identification of antiangiogenic and antiinflammatory proteins in human amniotic membrane" 19 : 348-352, 2000

19 Meller D, "Ex vivo preservation and expansion of human limbal epithelial stem cells on amniotic membrane cultures" 86 : 463-471, 2002

20 Yeom HY, "Effects of amniotic membrane after LASEK on epithelial healing, clinical and refractive outcomes" 45 : 195-202, 2004

21 Tseng SCG, "Downregulation of TGF- β1,β2,β3, and TGF-β receptor II expression in human corneal fibroblasts by amniotic membrane" 39 : 428-, 1998

22 Li DQ, "Differential expression and regulation of TGF-beta1, TGF-beta2, TGF-beta3, TGF-beta RI, TGFbeta RII and TGF-beta RIII in cultured human corneal, limbal,and conjunctival fibroblasts" 19 : 154-161, 1999

23 Meller D, "Conjunctival epithelial cell differentiation on amniotic membrane" 40 : 878-886, 1999

24 Kim JH, "Clinical evaluation of endoscopic transnasal dacryocystorhinostomy" 38 : 1706-1711, 1997

25 Kjaergaard N, "Chorioamniotic membranes constitute a competent barrier to group B streptococcus in vitro" 83 : 165-169, 1999

26 Guo M, "Basement membrane and human epidermal differentiation in vitro" 93 : 372-378, 1989

27 Kjaergaard N, "Antibacterial properties of human amnion and chorion in vitro" 94 : 224-229, 2001

28 Kim JH, "Amniotic membrane transplantation in perforation or impending perforation of cornea" 40 : 1487-1495, 1999

29 Chen HJ, "Amniotic membrane transplantation for severe neurotrophic corneal ulcers" 84 : 826-833, 2000

30 Lee SH, "Amniotic membrane transplantation for persistent epithelial defects with ulceration" 123 : 303-312, 1997

31 Meller D, "Amniotic membrane transplantation for acute chemical or thermal burns" 107 : 980-990, 2000

32 Letko E, "Amniotic membrane inlay and overlay grafting for corneal epithelial defects and stromal ulcers" 119 : 659-663, 2001

33 Bultmann S, "Amniotic membrane down-regulate chemokine expression in human keratocyte" 40 : 578-, 1999

34 Khodadoust AA, "Adhesion of regenerating corneal epithelium. The role of basement membrane" 65 : 339-348, 1968

35 Kong YT, "A report of 131 cases of endoscopic laser lacrimal surgery" 101 : 1793-1800, 1994