SM-101외 12종의 항생물질에 대한 항균력 시험 = Antimicrobial Activities of SM-101 and 12 Other Drugs Against Clinical Isolates

다국어 초록 (Multilingual Abstract)

SM-101, SP-102, SA-103, SB-104, SC-105, and SD-106, Korean products, were tested for its antimicrobial effect I comparison with those of ampicillin, amoxicillin, cefazolin, cefamandole, cefotaxime, sulbactam, and piperacillin. Minimal inhibitory concentrations of total 286 clinical isolates were determined by microdilution broth method and all of antimicrobials were tested at concentration from 0.125 to 128 ㎍/ml.
Ninety percent of coagulase-negative staphylococci were inhibited at 4 ㎍/ml of SB-104, SM-101 and SB-104 showed relatively lower MIC range against methicllin-susceptble Staphylococcus aureus. Ninety percent of ampicillin-susceptible E. coli were inhibited at 2 ㎍/ml of SP-102 and SC-105. Fifty percent of P. aeruginosa were inhibited at 8㎍/ml of SP-102 and SC-105. Compared to ampicillin, cefazolin, cefotaxime, and sulbactam, SM-101 and 5 other antimicrobials showed higher activities against Bacteroides spp, and SA-103 showed the lowest range of MIC against Bacteroides spp. Among 6 antimicrobial products, SD-106 showed the highest MIC range against all of clinical isolates.