우울 및 스트레스 정도에 따른 혈중 호모시스테인 농도

국문 초록 (Abstract)

본 연구는 우울 및 스트레스 정도에 따른 호모시스테인 농도에 어떠한 차이가 있는지를 알아보고자 하였다. 건강증진센터를 내원한 20세 이상 성인 1,395명을 대상으로 하여 8시간 이상 공복상태에서 신체계측 및 혈액검사를 시행하였으며 우울여부 및 스트레스 정도에 대한 자기기입식 설문조사를 시행하였다. 우울 여부에 대한 선별을 위하여 65세 미만에서는 CES-D (Center for Epidemiological Studies-Depression Scale) 한국판을, 65세 이상에서는 GDS (Geriatric Depression Scale) 단축판을 이용하여 우울군과 정상군 두 그룹으로 나누었으며, 스트레스에 정도에 대해서는 한국어판 BEPSI (Brief Encounter Psychosocial Instrument) score를 측정하여 그 정도에 따라 세 그룹으로 나누었다. 각 그룹별 혈중 호모시스테인 농도를 비교한 결과 상관관계가 있는 모든 변수들을 보정하자 나이에 상관없이 남녀모두 우울여부에 따른 혈중 호모시스테인 농도에는 차이가 없었으나, 스트레스 정도에 따른 비교해서는 남자에서 스트레스가 강도가 높을수록 혈중 호모시스테인 농도가 높은 경향을 보임을 알 수 있었다.

다국어 초록 (Multilingual Abstract)

In this study, we investigated plasma homocysteine concentration according to the depression and degree of stress. The study subjects were 1,395 adults aged over 20 years who visited a health promotion center. Medical history was recorded through a self-reported questionnaire and physical examination was performed on all subjects. We measured plasma homocysteine by blood sampling after fasting over 8 hours. To determine depression, we used CES-D in the subjects below the age of 65 and GDS over the age of 65. The stress group is divided into three subgruoups by using BEPSI. We adjusted for all variables that affect the homocysteine. The homocysteine concentration was not associated with depression regardless age and sex. There was significant differentiation of plasma homocysteine concentration according the degree of stress in men, but no differentiation in Women. This study showed no relationship between depression and plasma homocysteine concentration. We found that men in high stress group had a tendency for higher plasma homocysteine concentration.

목차 (Table of Contents)

• 서론
• 재료 및 방법
• 결과
• 고찰
• References
• 국문초록

참고문헌 (Reference)

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