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      KCI등재 SCOPUS

      Methidathion Poisoning

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      https://www.riss.kr/link?id=A104303683

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      다국어 초록 (Multilingual Abstract)

      Although methidathion is an organophosphate insecticide, it is different from the other organophosphates in terms of toxicity. Because of its relatively high fat solubility, the apparent volume of methidathion distribution throughout the body is very high, indicating that hemoperfusion is not effective in removing this organophosphate from the body. Redistribution of methidathion from fat to blood can also occur when plasma levels diminish. Additionally, acetylcholinesterase aging, which is the loss of an alkyl side chain that prevents reactivation by oximes, is very rapid so that the effective reactivation by oximes is thwarted. Thus, methidathion’s effect on acetylcholinesterase inhibition is long lasting, particularly with a high dose. In addition to its parasympatholytic effect and ability to induce muscle paralysis, methidathion poisoning is associated with a profound and long-lasting circulatory collapse due to sympathetic ganglion blockade. This report presents the case of a 55-year-old man who accidentally ingested a high dose of methidathion.
      He later developed enteroinvasive aspergillosis infection-induced multiple bowel perforations on two separate occasions while on mechanical ventilator support, resulting in a fatal outcome. The renin-angiotensin axis activated by sympathetic ganglion blockade may have reduced the patient’s splanchnic blood flow, contributing to translocation of endotoxin. Also, the effect of excessive acetylcholine on non-neuronal acetylcholine receptors may have contributed to the development of fatal enteroinvasive aspergillosis in this patient.
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      Although methidathion is an organophosphate insecticide, it is different from the other organophosphates in terms of toxicity. Because of its relatively high fat solubility, the apparent volume of methidathion distribution throughout the body is very ...

      Although methidathion is an organophosphate insecticide, it is different from the other organophosphates in terms of toxicity. Because of its relatively high fat solubility, the apparent volume of methidathion distribution throughout the body is very high, indicating that hemoperfusion is not effective in removing this organophosphate from the body. Redistribution of methidathion from fat to blood can also occur when plasma levels diminish. Additionally, acetylcholinesterase aging, which is the loss of an alkyl side chain that prevents reactivation by oximes, is very rapid so that the effective reactivation by oximes is thwarted. Thus, methidathion’s effect on acetylcholinesterase inhibition is long lasting, particularly with a high dose. In addition to its parasympatholytic effect and ability to induce muscle paralysis, methidathion poisoning is associated with a profound and long-lasting circulatory collapse due to sympathetic ganglion blockade. This report presents the case of a 55-year-old man who accidentally ingested a high dose of methidathion.
      He later developed enteroinvasive aspergillosis infection-induced multiple bowel perforations on two separate occasions while on mechanical ventilator support, resulting in a fatal outcome. The renin-angiotensin axis activated by sympathetic ganglion blockade may have reduced the patient’s splanchnic blood flow, contributing to translocation of endotoxin. Also, the effect of excessive acetylcholine on non-neuronal acetylcholine receptors may have contributed to the development of fatal enteroinvasive aspergillosis in this patient.

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      참고문헌 (Reference)

      1 Reilly PM, "Vasoactive mediators and splanchnic perfusion" 21 (21): S55-S68, 1993

      2 Eisendle M, "The siderophore system is essential for viability of Aspergillus nidulans: functional analysis of two genes encoding l-ornithine N 5-monooxygenase (sidA) and a non-ribosomal peptide synthetase (sidC)" 2 : 359-375, 2003

      3 Eyer P., "The role of oximes in the management o organophosphorus pesticide poisoning" 22 : 165-190, 2003

      4 Inglis DO, "The Candida genome database incorporates multiple Candida species: multispecies search and analysis tools with curated gene and protein information for Candida albicans and Candida glabrata" 40 (40): D667-D674, 2012

      5 Ramage G, "Strength in numbers: antifungal strategies against fungal biofilms" 43 : 114-120, 2014

      6 Lyte M, "Stimulation of Staphylococcus epidermis growth and biofilm formation by catecholamine inotropes" 361 : 130-135, 2003

      7 Freestone PP, "Pseudomonas aeruginosacatecholamine inotrope interactions: a contributory factor in the development of ventilator-associated pneumonia?" 142 : 1200-1210, 2012

      8 Russo A, "Predictors of mortality in nonneutropenic patients with invasive pulmonary aspergillosis:does galactomannan have a role?" 80 : 83-86, 2014

      9 Tokyay R, "Postburn gastrointestinal vasoconstriction increases bacterial and endotoxin translocation" 74 : 1521-1527, 1993

      10 Nelson DL, "Organophosphorus compounds; the past and the future" 5 : 223-230, 1972

      1 Reilly PM, "Vasoactive mediators and splanchnic perfusion" 21 (21): S55-S68, 1993

      2 Eisendle M, "The siderophore system is essential for viability of Aspergillus nidulans: functional analysis of two genes encoding l-ornithine N 5-monooxygenase (sidA) and a non-ribosomal peptide synthetase (sidC)" 2 : 359-375, 2003

      3 Eyer P., "The role of oximes in the management o organophosphorus pesticide poisoning" 22 : 165-190, 2003

      4 Inglis DO, "The Candida genome database incorporates multiple Candida species: multispecies search and analysis tools with curated gene and protein information for Candida albicans and Candida glabrata" 40 (40): D667-D674, 2012

      5 Ramage G, "Strength in numbers: antifungal strategies against fungal biofilms" 43 : 114-120, 2014

      6 Lyte M, "Stimulation of Staphylococcus epidermis growth and biofilm formation by catecholamine inotropes" 361 : 130-135, 2003

      7 Freestone PP, "Pseudomonas aeruginosacatecholamine inotrope interactions: a contributory factor in the development of ventilator-associated pneumonia?" 142 : 1200-1210, 2012

      8 Russo A, "Predictors of mortality in nonneutropenic patients with invasive pulmonary aspergillosis:does galactomannan have a role?" 80 : 83-86, 2014

      9 Tokyay R, "Postburn gastrointestinal vasoconstriction increases bacterial and endotoxin translocation" 74 : 1521-1527, 1993

      10 Nelson DL, "Organophosphorus compounds; the past and the future" 5 : 223-230, 1972

      11 Bull DL., "O-dimethyl phosphorodithioate S-ester with 4-(mercapto-methyl)-2-methoxy-Δ2-1,3,4-thiadiazolin-5-one (Geigy GS-13005) in plants and animals" 16 : 610-616, 1968

      12 Borghi E, "New strategic insights into managing fungal biofilms" 6 : 1077-, 2015

      13 Lass-Flörl C, "Minireview: host defence in invasive aspergillosis" 56 : 403-413, 2013

      14 Seon Ah Cha, "Invasive Primary Colonic Aspergillosis in the Immunocompetent Host without Classical Risk Factors" Yonsei University College of Medicine (KAMJE) 56 (56): 1453-, 2015

      15 Delamaire M, "Impaired leukocyte function in diabetic patients" 14 : 29-34, 1997

      16 Fiddian-Green RG, "Goals for the resuscitation of shock" 21 (21): S25-S31, 1993

      17 Roshchina VV, "An enzyme from the fungus Aspergillus niger that hydrolyzes choline ethers" 12 : 50-54, 1991

      18 Zoppellari R, "Acute poisoning with methidathion: a case" 9 : 415-419, 1990

      19 Rosas-Ballina M, "Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit" 334 : 98-101, 2011

      20 Rajendran R, "Acetylcholine protects against Candida albicans infection by inhibiting biofilm formation and promoting hemocyte function in a Galleria mellonella infection model" 14 : 834-844, 2015

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2025 평가예정 재인증평가 신청대상 (재인증)
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      2021-12-01 평가 등재후보로 하락 (재인증) KCI등재후보
      2018-02-28 학술지명변경 한글명 : The Korean Journal of Critical Care Medicine -> Acute and Critical Care
      외국어명 : The Korean Journal of Critical Care Medicine -> Acute and Critical Care
      KCI등재
      2018-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2016-06-24 학술지명변경 한글명 : 대한중환자의학회지 -> The Korean Journal of Critical Care Medicine
      외국어명 : The Korean Society of Critical Care Medicine -> The Korean Journal of Critical Care Medicine
      KCI등재
      2015-01-01 평가 등재학술지 선정 (계속평가) KCI등재
      2013-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2012-01-01 평가 등재후보학술지 유지 (기타) KCI등재후보
      2011-01-01 평가 등재후보 1차 FAIL (등재후보1차) KCI등재후보
      2009-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.07 0.07 0.09
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.1 0.08 0.289 0.12
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