전산화 단층촬영에 사용되는 조영제의 부작용 발생에 대한 분석 = Analysis of adverse reaction of contrast medium used in Computed Tomography

다국어 초록 (Multilingual Abstract)

Purpose
The objective of this article is to analyze the symptom of patients suffering the adverse reaction of contrast medium in CT test and the risk factor mat can cause adverse reaction in order to provide basic materials which contribute to find the method to reduce adverse reaction in advance.
Materials and Methods
Among the patients visiting university hospital from January to July, 2007, adults over 16 years old to whom contrast medium was applied into vein for CT test were chosen. Then, among them, 92 male and female patients who suffered the adverse reaction of contrast medium were selected as target. Analyzing backwardly the general property of testee recorded in the written consent for test which was received from patients or custodian before CT test and the former history of the adverse reaction of contrast medium, existence/unexistence of disease and the disease, the test result of patients (hypertension, allergy, asthma, medication adverse reaction, kidney disease, diabetes, digestive organ, respiratory organ, circulatory organ, nerve, hematogenesis, lymph, thyroid gland and other unidentified disease), the authors investigated the relation with adverse reaction and analyzed the risk factor of adverse reaction as per tested part, types of contrast, infusion quantity, infusion velocity in accordance with contrast medium applied to the testee. Further, the symptom of adverse reaction was analyzed in each type. Namely, actual number and percentage was analyzed in the division of dermal sensory system, respiratory organ, digestive organ, nerve system, circulatory organ, ophthalmologic system and so on. To analyze the risk factor of adverse reaction of testee after CT test, Chi-square test and simple/multiple regression analysis was adopted to diverse variables so as to analyze significance by using SPSS 10.0 statistical program.
Results
1. In the general property, the division of sex was 36 men(39.1%) and 56 women (60.9%), showing no significant difference in the analysis of sex on the symptom of adverse reaction(p=0.132). In the aspect of age, those in 50~59 years old showed the highest rate of adverse reaction -29 persons (31.5%) and those under 19 years old showed the lowest rate of adverse reaction -1 person (1.1%). Thus, the age analysis in the symptom of adverse reaction also showed no statistically significant difference(p=0.204). The occurrence of adverse reaction in each part of body for test also showed no significant difference from the symptom of adverse reaction of contrast medium (p=0.137).
2. In the case of type of contrast medium (p=0.093), infusion quantity (p=0.279), infusion velocity (p=0.314), there was no statistically significant difference from the symptom of adverse re-action of contrast medium. In the product of A-1,54 persons (58.7%), 61 persons (66.3%) in 121-130cc, 37 persons (40.2%) in 2.6-3.0cc/sec, respectively showing the highest distribution, namely, the symptom of adverse reaction.
In the former history of the contrast medium, 10 out of 92 persons(10.9%) were analyzed, thereby showing statistically significant difference(p=0.003).
3. In the analysis of adverse reaction of contrast medium as per history of disease, 9 patients(11%) of hypertension showed urticaria and itching, ex 7), 16 patients (19.5%) of allergic asthma showed urticaria and itching, ex 17) and flush, ex 5), 4 patients of medication adverse reaction (5.2%) showed flush, dermal edema, dizziness, ex 3), 3 patients(3.9%) of kidney disease showed urticaria and itching, ex 5), 32 patients(41.6%) of digestive organ disease, the highest distribution showed itching and urticaria, ex 30), flush, ex 11), 1 patient(1.3%) of nerve system disease showed urticaria and itching, dizziness, ex 2), 6 patients(7.8%) of thyroid gland disease showed urticaria and itching, ex 6), dyspnea, ex 2). Thus, the symptom of adverse reaction of contrast medium as per history of disease showed statistically significant difference(p=

목차 (Table of Contents)

• Abstract
• I. 서론
• II. 대상 및 방법
• III. 성적
• IV. 고찰
• 참고문헌