Further Characterization of Activin A-induced IgA Response in Murine B Lymphocytes

다국어 초록 (Multilingual Abstract)

We have recently shown that activin A, a member of TGF-β
superfamily, stimulates mouse B cells to express IgA isotype
but other isotypes. In the present study, we further characterized
effects of activin A on B cell growth and IgA
expression. We found that activin A did not have effect on
LPS-stimulated cell viability. In parallel, CFSE staining analysis
revealed that activin A did not alter cell division. An increase
of IgA secretion by activin A was completely abrogated
by anti-activin A Ab but not by anti-TGFβ1 Ab. In the
same conditions, no other isotypes are significantly affected
by each antibody treatment. Finally, activin A, as similar to
TGF-β1, increased IgA secretion by mesenteric lymph node
cells. These results suggest that activin A can specifically
stimulate IgA response, independent of TGF-β in the gut.

다국어 초록 (Multilingual Abstract)

We have recently shown that activin A, a member of TGF-β
superfamily, stimulates mouse B cells to express IgA isotype
but other isotypes. In the present study, we further characterized
effects of activin A on B cell growth and IgA
expression. We found that activin A did not have effect on
LPS-stimulated cell viability. In parallel, CFSE staining analysis
revealed that activin A did not alter cell division. An increase
of IgA secretion by activin A was completely abrogated
by anti-activin A Ab but not by anti-TGFβ1 Ab. In the
same conditions, no other isotypes are significantly affected
by each antibody treatment. Finally, activin A, as similar to
TGF-β1, increased IgA secretion by mesenteric lymph node
cells. These results suggest that activin A can specifically
stimulate IgA response, independent of TGF-β in the gut.

참고문헌 (Reference)

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