Post-transcriptional Regulation of NK Cell Activation

다국어 초록 (Multilingual Abstract)

Natural killer (NK) cells play key roles in innate and adaptive
immune defenses. NK cell responses are mediated by two
major mechanisms: the direct cytolysis of target cells, and
immune regulation by production of various cytokines. Many
previous reports show that the complex NK cell activation
process requires de novo gene expression regulated at both
transcriptional and post-transcriptional levels. Specialized
un-translated regions (UTR) of mRNAs are the main mechanisms
of post-transcriptional regulation. Analysis of posttranscriptional
regulation is needed to clearly understand NK
cell biology and, furthermore, harness the power of NK cells
for therapeutic aims. This review summarizes the current understanding
of mRNA metabolism during NK cell activation,
focusing primarily on post-transcriptional regulation.

다국어 초록 (Multilingual Abstract)

Natural killer (NK) cells play key roles in innate and adaptive
immune defenses. NK cell responses are mediated by two
major mechanisms: the direct cytolysis of target cells, and
immune regulation by production of various cytokines. Many
previous reports show that the complex NK cell activation
process requires de novo gene expression regulated at both
transcriptional and post-transcriptional levels. Specialized
un-translated regions (UTR) of mRNAs are the main mechanisms
of post-transcriptional regulation. Analysis of posttranscriptional
regulation is needed to clearly understand NK
cell biology and, furthermore, harness the power of NK cells
for therapeutic aims. This review summarizes the current understanding
of mRNA metabolism during NK cell activation,
focusing primarily on post-transcriptional regulation.

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