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      KCI등재 SCOPUS SCIE

      Post-transcriptional Regulation of NK Cell Activation

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      https://www.riss.kr/link?id=A103884185

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      다국어 초록 (Multilingual Abstract)

      Natural killer (NK) cells play key roles in innate and adaptive
      immune defenses. NK cell responses are mediated by two
      major mechanisms: the direct cytolysis of target cells, and
      immune regulation by production of various cytokines. Many
      previous reports show that the complex NK cell activation
      process requires de novo gene expression regulated at both
      transcriptional and post-transcriptional levels. Specialized
      un-translated regions (UTR) of mRNAs are the main mechanisms
      of post-transcriptional regulation. Analysis of posttranscriptional
      regulation is needed to clearly understand NK
      cell biology and, furthermore, harness the power of NK cells
      for therapeutic aims. This review summarizes the current understanding
      of mRNA metabolism during NK cell activation,
      focusing primarily on post-transcriptional regulation.
      번역하기

      Natural killer (NK) cells play key roles in innate and adaptive immune defenses. NK cell responses are mediated by two major mechanisms: the direct cytolysis of target cells, and immune regulation by production of various cytokines. Many previous repo...

      Natural killer (NK) cells play key roles in innate and adaptive
      immune defenses. NK cell responses are mediated by two
      major mechanisms: the direct cytolysis of target cells, and
      immune regulation by production of various cytokines. Many
      previous reports show that the complex NK cell activation
      process requires de novo gene expression regulated at both
      transcriptional and post-transcriptional levels. Specialized
      un-translated regions (UTR) of mRNAs are the main mechanisms
      of post-transcriptional regulation. Analysis of posttranscriptional
      regulation is needed to clearly understand NK
      cell biology and, furthermore, harness the power of NK cells
      for therapeutic aims. This review summarizes the current understanding
      of mRNA metabolism during NK cell activation,
      focusing primarily on post-transcriptional regulation.

      더보기

      다국어 초록 (Multilingual Abstract)

      Natural killer (NK) cells play key roles in innate and adaptive
      immune defenses. NK cell responses are mediated by two
      major mechanisms: the direct cytolysis of target cells, and
      immune regulation by production of various cytokines. Many
      previous reports show that the complex NK cell activation
      process requires de novo gene expression regulated at both
      transcriptional and post-transcriptional levels. Specialized
      un-translated regions (UTR) of mRNAs are the main mechanisms
      of post-transcriptional regulation. Analysis of posttranscriptional
      regulation is needed to clearly understand NK
      cell biology and, furthermore, harness the power of NK cells
      for therapeutic aims. This review summarizes the current understanding
      of mRNA metabolism during NK cell activation,
      focusing primarily on post-transcriptional regulation.
      번역하기

      Natural killer (NK) cells play key roles in innate and adaptive immune defenses. NK cell responses are mediated by two major mechanisms: the direct cytolysis of target cells, and immune regulation by production of various cytokines. Many previous ...

      Natural killer (NK) cells play key roles in innate and adaptive
      immune defenses. NK cell responses are mediated by two
      major mechanisms: the direct cytolysis of target cells, and
      immune regulation by production of various cytokines. Many
      previous reports show that the complex NK cell activation
      process requires de novo gene expression regulated at both
      transcriptional and post-transcriptional levels. Specialized
      un-translated regions (UTR) of mRNAs are the main mechanisms
      of post-transcriptional regulation. Analysis of posttranscriptional
      regulation is needed to clearly understand NK
      cell biology and, furthermore, harness the power of NK cells
      for therapeutic aims. This review summarizes the current understanding
      of mRNA metabolism during NK cell activation,
      focusing primarily on post-transcriptional regulation.

      더보기

      참고문헌 (Reference)

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      2 Shetty P, "Urokinase expression by tumor suppressor protein p53: a novel role in mRNA turnover" 39 : 364-372, 2008

      3 Ogilvie RL, "Tristetraprolin mediates interferon-gamma mRNA decay" 284 : 11216-11223, 2009

      4 Kruys V, "Translational blockade imposed by cytokine-derived UA-rich sequences" 245 : 852-855, 1989

      5 Shu Y, "Transcription, translation, degradation,and circadian clock" 321 : 1-6, 2004

      6 Jarzembowski JA, "The 5'-untranslated region of GM-CSF mRNA suppresses translational repression mediated by the 3' adenosine-uridine-rich element and the poly(A) tail" 27 : 3660-3666, 1999

      7 Dean JL, "The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR" 21 : 721-730, 2001

      8 Aggarwal BB, "TNF blockade: an inflammatory issue" 161-186, 2006

      9 Piecyk M, "TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha" 19 : 4154-4163, 2000

      10 Nagy E, "Selective modulation of IFN-gamma mRNA stability by IL-12/NKSF" 159 : 140-151, 1994

      1 Xu N, "Versatile role for hnRNP D isoforms in the differential regulation of cytoplasmic mRNA turnover" 21 : 6960-6971, 2001

      2 Shetty P, "Urokinase expression by tumor suppressor protein p53: a novel role in mRNA turnover" 39 : 364-372, 2008

      3 Ogilvie RL, "Tristetraprolin mediates interferon-gamma mRNA decay" 284 : 11216-11223, 2009

      4 Kruys V, "Translational blockade imposed by cytokine-derived UA-rich sequences" 245 : 852-855, 1989

      5 Shu Y, "Transcription, translation, degradation,and circadian clock" 321 : 1-6, 2004

      6 Jarzembowski JA, "The 5'-untranslated region of GM-CSF mRNA suppresses translational repression mediated by the 3' adenosine-uridine-rich element and the poly(A) tail" 27 : 3660-3666, 1999

      7 Dean JL, "The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR" 21 : 721-730, 2001

      8 Aggarwal BB, "TNF blockade: an inflammatory issue" 161-186, 2006

      9 Piecyk M, "TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha" 19 : 4154-4163, 2000

      10 Nagy E, "Selective modulation of IFN-gamma mRNA stability by IL-12/NKSF" 159 : 140-151, 1994

      11 Raineri I, "Roles of AUF1 isoforms, HuR and BRF1 in ARE-dependent mRNA turnover studied by RNA interference" 32 : 1279-1288, 2004

      12 Shetty S, "Regulation of urokinase receptor expression by p53: novel role in stabilization of uPAR mRNA" 27 : 5607-5618, 2007

      13 Hodge DL, "Regulation of nuclear gamma interferon gene expression by interleukin 12 (IL-12) and IL-2 represents a novel form of posttranscriptional control" 22 : 1742-1753, 2002

      14 Allgayer H, "Regulation and clinical significance of urokinase-receptor (u-PAR), an invasion-related molecule" 44 : 503-511, 2006

      15 Lykke-Andersen J, "Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1" 19 : 351-361, 2005

      16 Shetty S, "Protein synthesis and urokinase mRNA metabolism" 271 : 13-22, 2005

      17 Suarez-Alvarez B, "Potential role of NKG2D and its ligands in organ transplantation: new target for immunointervention" 9 : 251-257, 2009

      18 Velusamy T, "Posttranscriptional regulation of urokinase receptor expression by heterogeneous nuclear ribonuclear protein C" 47 : 6508-6517, 2008

      19 Sharma A, "Posttranscriptional regulation of interleukin-10 expression by hsa-miR-106a" 106 : 5761-5766, 2009

      20 Maroof A, "Posttranscriptional regulation of II10 gene expression allows natural killer cells to express immunoregulatory function" 29 : 295-305, 2008

      21 Fan XC, "Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs" 17 : 3448-3460, 1998

      22 Vély F, "Natural killer cell receptor signaling pathway in mammals" 12 : 2005

      23 Shi MM, "Molecular cloning and posttranscriptional regulation of macrophage inflammatory protein-1 alpha in alveolar macrophages" 211 : 289-295, 1995

      24 Eberhardt W, "Modulation of mRNA stability as a novel therapeutic approach" 114 : 56-73, 2007

      25 Brewer G, "Increased interleukin-10 mRNA stability in melanoma cells is associated with decreased levels of A+U-rich element binding factor AUF1" 23 : 553-564, 2003

      26 Al-Atrash G, "IL-2-mediated upregulation of uPA and uPAR in natural killer cells" 292 : 184-189, 2002

      27 Blount DG, "IL-10: the master regulator of immunity to infection" 180 : 5771-7577, 2008

      28 Stern-Ginossar N, "Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D" 9 : 1065-1073, 2008

      29 Katsanou V, "HuR as a negative posttranscriptional modulator in inflammation" 19 : 777-789, 2005

      30 Stern-Ginossar N, "Host immune sys tem gene targeting by a viral miRNA" 317 : 376-381, 2007

      31 Tarr PE, "Granulocyte-macrophage colony-stimulating factor and the immune system" 13 : 133-140, 1996

      32 Dranoff G, "GM-CSF-based cancer vaccines" 188 : 147-154, 2002

      33 Tsutsumi A, "Expression of tristetraprolin (G0S24) mRNA, a regulator of tumor necrosis factor-alpha production, in synovial tissues of patients with rheumatoid arthritis" 31 : 1044-1049, 2004

      34 Ford LP, "ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system" 13 : 188-201, 1999

      35 Cai SF, "Differential expression of granzyme B and C in murine cytotoxic lymphocytes" 182 : 6287-6297, 2009

      36 Buzby JS, "Developmental regulation of RNA transcript destabilization by A+U-rich elements is AUF1-dependent" 274 : 33973-33978, 1999

      37 Chowdhury D, "Death by a thousand cuts:granzyme pathways of programmed cell death" 26 : 389-420, 2008

      38 Paste M, "Deadenylation of interferon-beta mRNA is mediated by both the AU-rich element in the 3'-untranslated region and an instability sequence in the coding region" 270 : 1590-1597, 2003

      39 Muller WE, "Association of AUUUA-binding protein with A+U-rich mRNA during nucleo-cytoplasmic transport" 226 : 721-733, 1992

      40 Nemeth ZH, "Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism" 175 : 8260-8270, 2005

      41 Fehniger TA, "Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs" 26 : 798-811, 2007

      42 Sarkar S, "AUF1 isoform-specific regulation of anti-inflammatory IL10 expression in monocytes" 28 : 679-691, 2008

      43 Zhang T, "AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors" 30 : 952-958, 2002

      44 Shaw G, "A conserved AU sequence from the 3'untranslated region of GM-CSF mRNA mediates selective mRNA degradation" 46 : 659-667, 1986

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2025 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2022-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2021-12-01 평가 등재로 하락 (재인증) KCI등재
      2016-02-22 학회명변경 영문명 : Korean Association Of Immunbiologists -> The Korean Association of Immunologists
      2016-01-01 평가 우수등재학술지 선정 (계속평가)
      2012-01-01 평가 등재 1차 FAIL (등재유지) KCI등재
      2009-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2008-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2007-01-01 평가 등재후보학술지 유지 (등재후보2차) KCI등재후보
      2006-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2004-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.36 0.36 0.29
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.24 0.2 0.636 0
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