Effect of acute renal failure (ARF) on the hepatic metabolism of antipyrtine was investigated in the rat. Total body clearance (CL_t) of antipyrine was decreased (40%) significantly (p$lt;0.05) by ARF. ARF did not affect the hepatic plasma flow and ti...
Effect of acute renal failure (ARF) on the hepatic metabolism of antipyrtine was investigated in the rat. Total body clearance (CL_t) of antipyrine was decreased (40%) significantly (p$lt;0.05) by ARF. ARF did not affect the hepatic plasma flow and tissue distribution of antipyrine. The decrease in CL_t was attributed to the decrease in hepatic intrinsic clearance (CL_(int)) of antipyrine. Therefore, it seems to be noted that hepatic metabolism of drugs is damaged in some ARF models.