쇼그렌 증후군 환자에서 발생한 Mycobacterium Massiliense에 의한 재발성 폐렴 = A Case of Mycobacterium Massiliense Infection Presenting as Recurrent Pneumonia in Sjogren`s Syndrome

다국어 초록 (Multilingual Abstract)

Mycobacterium massiliense is an emerging pathogen that is increasingly reported as a causative agent occurring during medical procedures, at surgical sites, and intramuscularly [1]. Although previously classified as part of M. abscessus, M. massiliense has recently been identified as a new species of rapidly growing nontuberculous mycobacteria [1,3] via a comparative sequence analysis of rpoB and hsp65 [3,5]. However, the clinical manifestations of M. massiliense have not been well characterized. We report here in a case of recurrent pneumonia for 3 years that improved with antibiotic treatment for M. massiliense in a 37-year-old woman with Sjogren`s syndrome. The patient showed a substantial response to treatment with a combination of antimicrobial therapies comprising clarithromycin and amikacin without cefoxitin for 6 months. This is the first report of pulmonary infection of M. massiliense with Sjogren`s syndrome in Korea.

참고문헌 (Reference)

1 김정만, "비결핵항산균 감염증 환자에서 분리된 신속발육항산균의약제 감수성과 임상적 의의" 대한임상미생물학회 10 (10): 143-149, 2007

2 Kim HY, "Proportions of Mycobacterium massiliense and Mycobacterium bolletii strains among Korean Mycobacterium chelonae-Mycobacterium abscessus group isolates" 46 : 3384-3390, 2008

3 주세익, "Outbreak of Mycobacterium massiliense infection associated with intramuscular injections" AMER SOC MICROBIOLOGY 45 : 3127-3130, 200709

4 Management of opportunist mycobacterial infections, "Joint Tuberculosis Committee Guidelines 1999: Subcommittee of the Joint Tuberculosis Committee of the British Thoracic Society" 55 : 210-218, 2000

5 Simmon KE, "Identification of an emerging pathogen, Mycobacterium massiliense, by rpoB sequencing of clinical isolates collected in the United States" 45 : 1978-1980, 2007

6 Won-Jung Koh, "Diagnosis and Treatment of Nontuberculous Mycobacterial Pulmonary Diseases: A Korean Perspective" 대한의학회 20 (20): 913-925, 2005

7 Koh WJ, "Clinical significance of differentiation of Mycobacterium massiliense from Mycobacterium abscessus" 183 : 405-410, 2011

8 Bastian S, "Assessment of clarithromycin susceptibility in strains belonging to the Mycobacterium abscessus group by erm (41) and rrl sequencing" 55 : 775-781, 2011

9 Griffith DE, "An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases" 175 : 367-416, 2007

10 Jung-Wan Yoo, "A Case of Mycobacterium massiliense Infection Presenting as Pneumonia Resistant to Antibiotics in an Immunocompetent Host" 대한결핵및호흡기학회 69 (69): 39-42, 2010